ArticleScience advances2016
Extracellular electrical recording of pH-triggered bursts in C6 glioma cell populations.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Electrophysiological monitoring of nutrient stress inMRS advances · 2025Article
- D-Limonene InhibitsMolecules (Basel, Switzerland) · 2024Article
- Ion Channels in Gliomas-From Molecular Basis to Treatment.International journal of molecular sciences · 2023Review
- Acid-Sensing Ion Channels in Glial Cells.Membranes · 2022Review
- Doxorubicin-Loaded Gold Nanoarchitectures as a Therapeutic Strategy against Diffuse Intrinsic Pontine Glioma.Cancers · 2021Article
- Bioelectrical understanding and engineering of cell biology.Journal of the Royal Society, Interface · 2020Article
- Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Human Breast Cancer Cells Demonstrate Electrical Excitability.Frontiers in neuroscience · 2020Article
- Ultrasensitive System for Electrophysiology of Cancer Cell Populations: A Review.Bioelectricity · 2019Article
- Extracellular Electrophysiology in the Prostate Cancer Cell Model PC-3.Sensors (Basel, Switzerland) · 2019Article
- Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities.The journal of venomous animals and toxins including tropical diseases · 2019Review
- Ultrasensitive gold micro-structured electrodes enabling the detection of extra-cellular long-lasting potentials in astrocytes populations.Scientific reports · 2017Article
- Extracellular Electrophysiological Measurements of Cooperative Signals in Astrocytes Populations.Frontiers in neural circuits · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioma patients often suffer from epileptic seizures because of the tumor's impact on the brain physiology. Using the rat glioma cell line C6 as a model system, we performed long-term live recordings of the electrical activity of glioma populations in an ultrasensitive detection method. The transducer exploits large-area electrodes that maximize double-layer capacitance, thus increasing the sensitivity. This strategy allowed us to record glioma electrical activity. We show that although glioma cells are nonelectrogenic, they display a remarkable electrical burst activity in time. The low-frequency current noise after cell adhesion is dominated by the flow of Na
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.