Evidence map›Paper›PMID 28028514›Full record

ArticleAdvanced biomedical research2016

The effect of melatonin on endothelial dysfunction in patient undergoing coronary artery bypass grafting surgery.

Shaghayegh Haghjooy Javanmard, Kiyan Heshmat-Ghahdarijani, Mohsen Mirmohammad-Sadeghi, Sayed Ali Sonbolestan, Amin Ziayi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biomedical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 5 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  6. Trial
  7. Article
  8. Review
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  11. Review
  12. Melatonin for the Management of Preeclampsia: A Review.Antioxidants (Basel, Switzerland) · 2021
    Review
  13. Article
  14. Is Melatonin the Cornucopia of the 21st Century?Antioxidants (Basel, Switzerland) · 2020
    Review
  15. Article
  16. Article
  17. Low serum melatonin levels are associated with erectile dysfunction.International braz j urol : official journal of the Brazilian Society of Urology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shaghayegh Haghjooy JavanmardDepartment of Physiology, Physiology Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Kiyan Heshmat-GhahdarijaniDepartment of Physiology, Physiology Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohsen Mirmohammad-SadeghiDepartment of Cardiac Surgery, Isfahan Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Sayed Ali SonbolestanDepartment of Physiology, Physiology Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
Amin ZiayiMedical Student Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we investigated the effect of melatonin administration on four markers of endothelial cell function including intercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), C-reactive protein (CRP), and nitric oxide (NO) on patients with three vessels coronary disease. MATERIALS AND

methodsThis double-blind, randomized, controlled trial study was conducted on 39 patients (32 men and 7 women) with three vessels coronary disease. The case group included 20 patients who received 10 mg oral melatonin 1 h before sleeping for 1 month. The control group included 19 patients who received placebo 1 h before sleeping for 1 month. The serum levels of CRP, ICAM, VCAM, and NO were compared after 1 month treatment.

resultsAfter 1 month of melatonin treatment, the mean level of ICAM, VCAM, and CRP showed a statistically significant decrease in the case group. On the other hand, the mean level of VCAM increased significantly in the control group. The mean levels of CRP and ICAM were also increased in the control group, but the difference did not reach the significant threshold. With respect to NO, there was a statistically significant increase in the case group, while there was a statistically significant decrease in serum NO in the control group.

conclusionsThe results of this study suggested that melatonin may have beneficial effects on endothelial oxidative stress even in patient with severe and advanced atherosclerosis.

Indexed as

Computer-aided designendothelial dysfunctionintercellular adhesion moleculemelatoninvascular cell adhesion molecule

Identifiers

PMID28028514
PMCPMC5156974
OpenAlexW2557405916

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.