ArticleWorld journal of gastroenterology2016
Characterization of smooth muscle, enteric nerve, interstitial cells of Cajal, and fibroblast-like cells in the gastric musculature of patients with diabetes mellitus.
Article in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Electrogastrography in Adult Gastroparesis: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2025Pooled it
- Review
- Early gastric dilation after laparoscopic sleeve gastrectomy: Insights from a three-dimensional computed tomography reconstruction study.World journal of gastrointestinal surgery · 2026Article
- Faecal microbiota transplantation for patients with diabetes type 1 and severe gastrointestinal neuropathy (FADIGAS): a randomised, double-blinded, placebo-controlled trial.EClinicalMedicine · 2025Article
- Article
- CaPhysiological reviews · 2024Review
- Predictive value of preoperative ultrasonographic measurement of gastric morphology for the occurrence of postoperative nausea and vomiting among patients undergoing gynecological laparoscopic surgery.Frontiers in oncology · 2024Article
- Reconsideration of the Gastroparetic Syndrome.Current gastroenterology reports · 2023Review
- Motor Dysfunction of Gastric Antral Smooth Muscle in Diabetic Rats: Contribution of ATP-Dependent Potassium Channels.Advanced biomedical research · 2023Article
- Telocytes' Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review.International journal of molecular sciences · 2022Review
- Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Article
- Xiangbinfang granules enhance gastric antrum motilityWorld journal of gastroenterology · 2021Article
- Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility.International journal of molecular sciences · 2020Review
- Spatial relationship between telocytes, interstitial cells of Cajal and the enteric nervous system in the human ileum and colon.Journal of cellular and molecular medicine · 2020Article
- Impaired neural pathway in gastric muscles of patients with diabetes.Scientific reports · 2018Article
- Does Size Matter? Correlation of Excised Gastric Specimen Size in Sleeve Gastrectomy to Postoperative Weight Loss and Comorbidities.Obesity surgery · 2018Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate histologic abnormalities in the gastric smooth muscle of patients with diabetes mellitus (DM).
methodsFull-thickness gastric specimens were obtained from patients undergoing surgery for gastric cancer. H&E stain and Masson's Trichrome stain were performed to assess the degree of fibrosis. Immunohistochemical staining using various antibodies was also performed [antibodies against protein gene product 9.5 (PGP9.5), neuronal nitric oxide synthase (nNOS), vasoactive intestinal peptide (VIP), neurokinin-1 (NK1) receptor, c-Kit, and platelet-derived growth factor receptor-alpha, (PDGFRα)]. Immunofluorescent staining and evaluation with confocal microscopy were also conducted.
resultsTwenty-six controls and 35 diabetic patients (21 short-duration patients and 14 long-duration patients) were included. There were no significant differences in basic demographics between the two groups except in mean body mass index (BMI) (higher in the DM group). Proportions of moderate-to-severe intercellular fibrosis in the muscle layer were significantly higher in the DM group than in the control group (
conclusionOur study suggests that increased intercellular fibrosis, loss of ICC, and loss of fibroblast-like cells are found in the smooth muscle of DM patients. These abnormalities may contribute to changes in gastric motor activity in patients with DM.
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