Evidence map›Paper›PMID 28028248›Full record

ArticleNanotechnology2017

Facile fabrication of tissue-engineered constructs using nanopatterned cell sheets and magnetic levitation.

Nisa Penland, Eunpyo Choi, Mikael Perla, Jungyul Park, Deok-Ho Kim

Abstract read
In one paragraph

Article in Nanotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Magnetic-Based Human Tissue 3D Cell Culture: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Reversible Design of Dynamic Assemblies at Small Scales.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nisa PenlandDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States.
Eunpyo ChoiDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States.ORCID 0000-0002-9689-6520
Mikael PerlaDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States.
Jungyul ParkDepartment of Mechanical Engineering, Sogang University, Seoul, Republic of Korea.
Deok-Ho KimDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States.ORCID 0000-0002-6989-6074

Funding

TISSUE ENGINEERED HUMAN NEUROMUSCULAR JUNCTIONS FOR MODELING AXONAL NEUROPATHYR01NS094388 · NINDS · UNIVERSITY OF WASHINGTON · PI KIM, DEOK-HO · 2017 to 2021
$1.7M
Injectable myocardial matrix-grapheme composite hydrogels for functional cardiac tissue engineeringR21EB020132 · NIBIB · UNIVERSITY OF WASHINGTON · PI KIM, DEOK-HO · 2016 to 2017
$435k
Nanopatterned 3D Vascularized Functional Muscle PatchR21AR064395 · NIAMS · UNIVERSITY OF WASHINGTON · PI KIM, DEOK-HO · 2014 to 2015
$421k
NIAMS NIH HHS R21 AR064395NIBIB NIH HHS R21 EB020132NINDS NIH HHS R01 NS094388
6 · The paper itself

Abstract

We report a simple and versatile method for in vitro fabrication of scaffold-free tissue-engineered constructs with predetermined cellular alignment, by combining magnetic cell levitation with thermoresponsive nanofabricated substratum (TNFS) based cell sheet engineering technique. The TNFS based nanotopography provides contact guidance cues for regulation of cellular alignment and enables cell sheet transfer, while magnetic nanoparticles facilitate the magnetic levitation of the cell sheet. The temperature-mediated change in surface wettability of the thermoresponsive poly(N-isopropylacrylamide), substratum enables the spontaneous detachment of cell monolayers, which can then be easily manipulated through use of a ring or disk shaped magnet. Our developed platform could be readily applicable to production of tissue-engineered constructs containing complex physiological structures for the study of tissue structure-function relationships, drug screening, and regenerative medicine.

Indexed as

Magnetic FieldsAcrylamidesAnimalsCell Culture TechniquesCell LineMagnetite NanoparticlesMagnetsMiceMyoblastsTissue EngineeringWettabilityAcrylamidesMagnetite NanoparticlesN-isopropylacrylamide

Identifiers

PMID28028248
PMCPMC5305271

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.