ArticleProceedings of the National Academy of Sciences of the United States of America2017
Lanthanide-dependent cross-feeding of methane-derived carbon is linked by microbial community interactions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
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Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 207 citations in OpenAlex.
- Leveraging genome-scale metabolic models to understand aerobic methanotrophs.The ISME journal · 2024Pooled it
- Source-Independent Enrichment of Light Lanthanides: Microbial Mobilization, Selective Uptake, and Intracellular Storage.Environmental microbiology · 2026Article
- Niche Compartmentalization Promotes Dissolved Methane Removal and Simultaneous Nitrification and Denitrification in a Hybrid MABR.Environmental science & technology · 2026Article
- Methane-fed microbial communities enriched from field-grown rice support diverse heterotrophic bacteria.FEMS microbiology ecology · 2026Article
- Microbial interaction networks as climate thermometers: redefining temperature sensitivity of aerobic methanotrophy in freshwater ecosystems.npj biodiversity · 2026Article
- Gut microbiota response to Enterocytozoon bieneusi infection in wild rodents: enhanced vitamin B and KBMC genomics · 2026Article
- Linking microbes toFrontiers in microbiology · 2026Article
- Inverse stable isotope probing-metabolomics (InverSIP) identifies an iron acquisition system in a methane-oxidizing bacterial community.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring biogeochemical transformation in a hypertrophic lake with dual focus on environmental cues and potential functional fingerprints of littoral bacteria.Scientific reports · 2025Article
- Novel energy utilization mechanisms of microorganisms in the hydrosphere.Fundamental research · 2025Review
- Methane-powered sea spiders: Diverse, epibiotic methanotrophs serve as a source of nutrition for deep-sea methane seepProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Emerging role of rare earth elements in biomolecular functions.The ISME journal · 2025Review
- Extensive and diverse lanthanide-dependent metabolism in the ocean.The ISME journal · 2025Article
- Proteomic evidence for aerobic methane production in groundwater by methylotrophic Methylotenera.The ISME journal · 2025Article
- Differential analysis of the quality and soil microhabitat ofFrontiers in microbiology · 2025Article
- Expanding the C-S-R framework to incorporate microbial interactions: evidence from methane-consuming communities.Frontiers in microbiology · 2025Article
- Methanotroph-methylotroph lipid adaptations to changing environmental conditions.Frontiers in microbiology · 2025Article
- Research potential and mechanism of rare earth elements promoting cadmium remediation efficiency in hyperaccumulator plants.Frontiers in plant science · 2025Article
- A novel in-silico model explores LanM homologs among Hyphomicrobium spp.Communications biology · 2024Article
- Methane cycling in temperate forests.Carbon balance and management · 2024Review
23 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The utilization of methane, a potent greenhouse gas, is an important component of local and global carbon cycles that is characterized by tight linkages between methane-utilizing (methanotrophic) and nonmethanotrophic bacteria. It has been suggested that the methanotroph sustains these nonmethanotrophs by cross-feeding, because subsequent products of the methane oxidation pathway, such as methanol, represent alternative carbon sources. We established cocultures in a microcosm model system to determine the mechanism and substrate that underlay the observed cross-feeding in the environment. Lanthanum, a rare earth element, was applied because of its increasing importance in methylotrophy. We used co-occurring strains isolated from Lake Washington sediment that are involved in methane utilization: a methanotroph and two nonmethanotrophic methylotrophs. Gene-expression profiles and mutant analyses suggest that methanol is the dominant carbon and energy source the methanotroph provides to support growth of the nonmethanotrophs. However, in the presence of the nonmethanotroph, gene expression of the dominant methanol dehydrogenase (MDH) shifts from the lanthanide-dependent MDH (XoxF)-type, to the calcium-dependent MDH (MxaF)-type. Correspondingly, methanol is released into the medium only when the methanotroph expresses the MxaF-type MDH. These results suggest a cross-feeding mechanism in which the nonmethanotrophic partner induces a change in expression of methanotroph MDHs, resulting in release of methanol for its growth. This partner-induced change in gene expression that benefits the partner is a paradigm for microbial interactions that cannot be observed in studies of pure cultures, underscoring the importance of synthetic microbial community approaches to understand environmental microbiomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.