Evidence map›Paper›PMID 28028216›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport.

Susanne Milatz, Nina Himmerkus, Vera Christine Wulfmeyer, Hoora Drewell, Kerim Mutig, Jianghui Hou, Tilman Breiderhoff, Dominik Müller, Michael Fromm, Markus Bleich and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
  2. Tight junction structure, assembly and (dys)function.Nature reviews. Molecular cell biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Endocrine regulation of uromodulin in aging.Frontiers in endocrinology · 2026
    Review
  10. Control of renal calcium permeability via a tight junctional claudin switch.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Calcium-Sensing Receptor in the Thick Ascending Limb and Renal Response to Hypercalcemia.Journal of the American Society of Nephrology : JASN · 2025
    Article
  14. Article
  15. Flow-dependent transport processes 2024: filtration, absorption, and secretion.American journal of physiology. Renal physiology · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Susanne MilatzInstitute of Physiology, Christian-Albrechts-University of Kiel, 24098 Kiel, Germany; s.milatz@physiologie.uni-kiel.de.ORCID 0000-0001-9893-0473
Nina HimmerkusInstitute of Physiology, Christian-Albrechts-University of Kiel, 24098 Kiel, Germany.ORCID 0000-0002-2910-6728
Vera Christine WulfmeyerInstitute of Physiology, Christian-Albrechts-University of Kiel, 24098 Kiel, Germany.
Hoora DrewellDepartment of Anatomy, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Kerim MutigDepartment of Anatomy, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Jianghui HouRenal Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Tilman BreiderhoffInstitute of Clinical Physiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Dominik MüllerDepartment of Pediatric Nephrology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Michael FrommInstitute of Clinical Physiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Markus BleichInstitute of Physiology, Christian-Albrechts-University of Kiel, 24098 Kiel, Germany.
Dorothee GünzelInstitute of Clinical Physiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEChristian-Albrechts-Universität zu Kiel · DEWashington University in St. Louis · US

Funding

BIOCHEMICAL AND BIOPHYSICAL NATURE OF CLAUDIN-16 AND CLAUDIN-19 CHANNELSR01DK084059 · NIDDK · WASHINGTON UNIVERSITY · PI HOU, JIANGHUI · 2010 to 2018
$2.9M
NIDDK NIH HHS R01 DK084059
6 · The paper itself

Abstract

The thick ascending limb (TAL) of Henle's loop drives paracellular Na

Indexed as

AnimalsClaudinsHEK293 CellsHumansLoop of HenleMagnesiumMice, Inbred C57BLMice, KnockoutRats, Sprague-DawleySodiumTight JunctionsClaudinsMagnesiumSodiumclaudin interactionFRETmicroperfusionparacellular ion transporttight junction

Identifiers

PMID28028216
PMCPMC5240732
OpenAlexW2567518196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.