Evidence map›Paper›PMID 28028214›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Arginine substitution of a cysteine in transmembrane helix M8 converts Na+,K+-ATPase to an electroneutral pump similar to H+,K+-ATPase.

Rikke Holm, Jaanki Khandelwal, Anja P Einholm, Jens P Andersen, Pablo Artigas, Bente Vilsen

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. NaBiomolecules · 2024
    Article
  2. A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Structure and function of HNature communications · 2022
    Article
  4. Article
  5. Article
  6. Displacement of the NaProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. Review
  8. Article
  9. A single KeLife · 2019
    Article
  10. KScientific reports · 2018
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rikke HolmDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Jaanki KhandelwalDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX 79430.
Anja P EinholmDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Jens P AndersenDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Pablo ArtigasDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX 79430 bv@biomed.au.dk pablo.artigas@ttuhsc.edu.
Bente VilsenDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark; bv@biomed.au.dk pablo.artigas@ttuhsc.edu.
Aarhus University · DKTexas Tech University · USTexas Tech University Health Sciences Center · US

Funding

Physiologically relevant energetic interactions within the Na/K PumpR15NS081570 · NINDS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI ARTIGAS, PABLO · 2013 to 2013
$453k
NINDS NIH HHS R15 NS081570
6 · The paper itself

Abstract

Na

Indexed as

Amino Acid SubstitutionArginineCysteineBinding, CompetitiveBinding SitesCationsCell MembraneHemiplegiaH(+)-K(+)-Exchanging ATPaseHumansIon ChannelsIon TransportModels, MolecularMutagenesis, Site-DirectedPhenylalaninePotassiumArginineCationsCysteineH(+)-K(+)-Exchanging ATPaseIon ChannelsPhenylalaninePotassiumProtein SubunitsProton PumpsSodiumSodium-Potassium-Exchanging ATPasealternating hemiplegia of childhoodelectrogenicityH+,K+-pumpinternal cationNa+,K+-pump

Identifiers

PMID28028214
PMCPMC5240710
OpenAlexW2567714299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.