Evidence map›Paper›PMID 28028193›Full record

ArticleHypertension (Dallas, Tex. : 1979)2017

Smooth Muscle Endothelin B Receptors Regulate Blood Pressure but Not Vascular Function or Neointimal Remodeling.

Eileen Miller, Alicja Czopek, Karolina M Duthie, Nicholas S Kirkby, Elisabeth E Fransen van de Putte, Sibylle Christen, Robert A Kimmitt, Rebecca Moorhouse, Raphael F P Castellan, Yuri V Kotelevtsev and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Orthogonal Peptide-Templated Labeling Elucidates Lateral ETChembiochem : a European journal of chemical biology · 2022
    Article
  5. Article
  6. Article
  7. Renal denervation attenuates hypertension but not salt sensitivity in ETAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Eileen MillerFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Alicja CzopekFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Karolina M DuthieFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Nicholas S KirkbyFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Elisabeth E Fransen van de PutteFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Sibylle ChristenFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Robert A KimmittFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Rebecca MoorhouseFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Raphael F P CastellanFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Yuri V KotelevtsevFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Rhoda E KucFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Anthony P DavenportFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Neeraj DhaunFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
David J WebbFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.).
Patrick W F HadokeFrom the University/BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (E.M., A.C., K.M.D., N.S.K., E.E.F.v.d.P., R.A.K., R.M., R.F.P.C., N.D., D.J.W., P.W.F.H.); University of Basel, Switzerland (S.C.); Centre for Functional Genomics, Skolkovo Institute of Science and Technology, Russian Federation (Y.V.K.); and Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom (R.E.K., A.P.D.). Patrick.Hadoke@ed.ac.uk.
Skolkovo Institute of Science and Technology · RUUniversity of Basel · CH

Funding

British Heart Foundation FS/13/30/29994British Heart Foundation FS/16/1/31699British Heart Foundation PG/08/068/25461Wellcome Trust 107715/Z/15/Z
6 · The paper itself

Abstract

The role of smooth muscle endothelin

Indexed as

Gene Expression RegulationAnimalsBlood PressureCells, CulturedDisease Models, AnimalHypertensionMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularNeointimaReal-Time Polymerase Chain ReactionReceptor, Endothelin BRNAVascular RemodelingVasoconstrictionReceptor, Endothelin BRNAautoradiographyendothelin-1hypertensionneointimavasoconstriction

Identifiers

PMID28028193
PMCPMC5222555
OpenAlexW2564120117

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.