ArticleThe Journal of experimental medicine2017
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
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Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
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Who cites it
36 citing papers in PubMed, 51 citations in OpenAlex.
- In Silico Systems Biology Approach for Prioritization of Candidate Genes Linked to Lipid Metabolism in the Context of Cardiovascular Disease Susceptibility in a Serbian Cohort.Current issues in molecular biology · 2026Article
- Comprehensive Profiling of T- and B-Cell Receptor Repertoires Demonstrates Impaired Developmental and Activation of Adaptive Immunity in DOCK8 Deficiency.Journal of clinical immunology · 2026Article
- A hypothesis and evidence map for neuroimmune regulation of DOCK-family cytoskeletal programs in solid tumors.Frontiers in immunology · 2026Review
- Decoding Rho GTPase signalling networks in directed cell migration.Frontiers in cell and developmental biology · 2026Review
- DOCK8 in immune cells: roles and mechanisms.Frontiers in immunology · 2026Review
- Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response.PLoS pathogens · 2024Article
- CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation.Nature communications · 2024Article
- Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia.Nature communications · 2024Article
- Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion.Cell reports · 2023Article
- Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.British journal of cancer · 2023Article
- DOCK8 interference alleviates Aβ‑induced damage of BV2 cells by inhibiting STAT3/NLRP3/NF‑κB signaling.Experimental and therapeutic medicine · 2023Article
- Deconvolution of bulk tumors into distinct immune cell states predicts colorectal cancer recurrence.iScience · 2022Article
- dock8 deficiency attenuates microglia colonization in early zebrafish larvae.Cell death discovery · 2022Article
- CRISPR/Cas-Based Gene Editing Strategies for DOCK8 Immunodeficiency Syndrome.Frontiers in genome editing · 2022Article
- Hyper-IgE Syndrome due to an Elusive Novel Intronic Homozygous Variant in DOCK8.Journal of clinical immunology · 2022Article
- Cutting Edge: DOCK8 Regulates a Subset of Dendritic Cells That Is Critical for the Development of Experimental Autoimmune Encephalomyelitis.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression.BMC cancer · 2021Article
- Migration-induced cell shattering due to DOCK8 deficiency causes a type 2-biased helper T cell response.Nature immunology · 2020Article
- Digital Image Analysis Applied to Tumor Cell Proliferation, Aggressiveness, and Migration-Related Protein Synthesis in Neuroblastoma 3D Models.International journal of molecular sciences · 2020Article
- LRCH1 deficiency enhances LAT signalosome formation and CD8Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Xiaoyan XuKey Laboratory of Systems Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, University of Chinese Academy of Sciences, Shanghai 200031, China.
Lei HanKey Laboratory of Systems Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, University of Chinese Academy of Sciences, Shanghai 200031, China.
Guixian ZhaoHuaShan Hospital, Fudan University, Shanghai 200031, China.
Shengjie XueKey Laboratory of Systems Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0001-9298-9124
Yunzhen GaoKey Laboratory of Systems Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-3221-0542
Jun XiaoKey Laboratory of Systems Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, University of Chinese Academy of Sciences, Shanghai 200031, China.
Shicheng ZhangNational Center for Protein Science Shanghai and State Key Laboratory of Biochemistry, CAS, University of Chinese Academy of Sciences, Shanghai 201203, China.
Peng ChenKey Laboratory of Systems Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-6471-2766
Zhi-Ying WuDepartment of Neurology and Research Center of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Jianping DingNational Center for Protein Science Shanghai and State Key Laboratory of Biochemistry, CAS, University of Chinese Academy of Sciences, Shanghai 201203, China.
Ronggui HuKey Laboratory of Systems Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, University of Chinese Academy of Sciences, Shanghai 200031, China.
Bin WeiState Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-2731-489X
Hongyan WangKey Laboratory of Systems Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, CAS, University of Chinese Academy of Sciences, Shanghai 200031, China hongyanwang@sibcb.ac.cn.ORCID 0000-0002-4074-3699
Shanghai Institutes for Biological Sciences · CNChinese Academy of Sciences · CNFudan University · CNSecond Affiliated Hospital of Zhejiang University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Directional autoreactive CD4
Indexed as
Animalscdc42 GTP-Binding ProteinCell MovementEncephalomyelitis, Autoimmune, ExperimentalGuanine Nucleotide Exchange FactorsMiceMice, Inbred C57BLMicrofilament ProteinsMultiple SclerosisPhosphorylationProtein Kinase C-alphaT-Lymphocytescdc42 GTP-Binding ProteinCdc42 protein, mouseDock8 protein, mouseGuanine Nucleotide Exchange FactorsLRCH1 protein, humanMicrofilament ProteinsPrkca protein, mouseProtein Kinase C-alpha
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.