Evidence map›Paper›PMID 28028118›Full record

ArticleAmerican journal of clinical pathology2016

Rapid Evaluation of Platelet Function With T2 Magnetic Resonance.

Adam Cuker, Holleh Husseinzadeh, Tatiana Lebedeva, Joseph E Marturano, Walter Massefski, Thomas J Lowery, Michele P Lambert, Charles S Abrams, John W Weisel, Douglas B Cines

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of clinical pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Blood clot contraction: Mechanisms, pathophysiology, and disease.Research and practice in thrombosis and haemostasis · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Adam CukerFrom the Departments of Medicine.
Holleh HusseinzadehFrom the Departments of Medicine.
Tatiana LebedevaPathology and Laboratory Medicine.
Joseph E MarturanoT2 Biosystems, Lexington, MA.
Walter MassefskiT2 Biosystems, Lexington, MA.
Thomas J LoweryT2 Biosystems, Lexington, MA.
Michele P LambertHematology Division, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
Charles S AbramsFrom the Departments of Medicine.
John W WeiselCell and Developmental Biology, University of Pennsylvania, Philadelphia.
Douglas B CinesFrom the Departments of Medicine dcines@mail.med.upenn.edu.
University of Pennsylvania · US

Funding

Subcellular Mechanisms pf Platelet ActivationP01HL040387 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BENNETT, JOEL S. · 1988 to 2018
$35.5M
Thrombosis Models CoreP01HL120846 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ABRAMS, CHARLES S. · 2014 to 2018
$12.2M
TRAINING GRANT IN HEMOSTASIS AND THROMBOSIST32HL007971 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Rodney M Camire · 2001 to 2026
$10.6M
Multiscale modeling and empirical study of a mechanism limiting blood clot growthU01HL116330 · NHLBI · UNIVERSITY OF NOTRE DAME · PI ALBER, MARK · 2014 to 2018
$3.5M
Structural origin of fibrin clot mechanical propertiesR56HL090774 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEISEL, JOHN W · 2014 to 2014
$408k
NHLBI NIH HHS P01 HL040387NHLBI NIH HHS P01 HL120846NHLBI NIH HHS R56 HL090774NHLBI NIH HHS T32 HL007971NHLBI NIH HHS U01 HL116330
6 · The paper itself

Abstract

objectivesThe clinical diagnosis of qualitative platelet disorders (QPDs) based on light transmission aggregometry (LTA) requires significant blood volume, time, and expertise, all of which can be barriers to utilization in some populations and settings. Our objective was to develop a more rapid assay of platelet function by measuring platelet-mediated clot contraction in small volumes (35 µL) of whole blood using T2 magnetic resonance (T2MR).

methodsWe established normal ranges for platelet-mediated clot contraction using T2MR, used these ranges to study patients with known platelet dysfunction, and then evaluated agreement between T2MR and LTA with arachidonic acid, adenosine diphosphate, epinephrine, and thrombin receptor activator peptide.

resultsBlood from 21 healthy donors was studied. T2MR showed 100% agreement with LTA with each of the four agonists and their cognate inhibitors tested. T2MR successfully detected abnormalities in each of seven patients with known QPDs, with the exception of one patient with a novel mutation leading to Hermansky-Pudlak syndrome. T2MR appeared to detect platelet function at similar or lower platelet counts than LTA.

conclusionsT2MR may provide a clinically useful approach to diagnose QPDs using small volumes of whole blood, while also providing new insight into platelet biology not evident using plasma-based platelet aggregation tests.

Indexed as

Magnetic Resonance SpectroscopyAspirinBlood Platelet DisordersBlood PlateletsHumansPlatelet ActivationPlatelet AggregationPlatelet Aggregation InhibitorsPlatelet Function TestsAspirinPlatelet Aggregation InhibitorsBlood clottingBlood plateletsClot retractionIn vitro diagnostic devicesPlatelet function testsT2 magnetic resonance

Identifiers

PMID28028118
PMCPMC5225753
OpenAlexW2565600596

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.