ArticleDiabetes2017
Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.
Open access · bronzeAbstract read
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Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Coordinated expression and assembly of BiP, p58Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis.The Journal of clinical investigation · 2026Article
- The role of ER-associated degradation and ER-phagy in health and disease.Signal transduction and targeted therapy · 2026Review
- Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy.Trends in cell biology · 2025Review
- Excess dietary sodium restores electrolyte and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron.American journal of physiology. Renal physiology · 2025Article
- Exploring proinsulin proteostasis: insights into beta cell health and diabetes.Frontiers in molecular biosciences · 2025Review
- Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function.Molecular biology of the cell · 2024Article
- Excess dietary sodium partially restores salt and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron.bioRxiv : the preprint server for biology · 2024Article
- Article
- Lhs1 dependent ERAD is determined by transmembrane domain context.The Biochemical journal · 2023Article
- PIMT Controls Insulin Synthesis and Secretion through PDX1.International journal of molecular sciences · 2023Article
- Viruses Hijack ERAD to Regulate Their Replication and Propagation.International journal of molecular sciences · 2022Review
- Insulin Null β-cells Have a Prohormone Processing Defect That Is Not Reversed by AAV Rescue of Proinsulin Expression.Endocrinology · 2022Article
- The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice.JCI insight · 2022Article
- Review
- PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones.Nature communications · 2021Article
- Distinct states of proinsulin misfolding in MIDY.Cellular and molecular life sciences : CMLS · 2021Article
- Normal and defective pathways in biogenesis and maintenance of the insulin storage pool.The Journal of clinical investigation · 2021Review
- Defects in Protein Folding and/or Quality Control Cause Protein Aggregation in the Endoplasmic Reticulum.Progress in molecular and subcellular biology · 2021Article
- SUMOylation of Pdia3 exacerbates proinsulin misfolding and ER stress in pancreatic beta cells.Journal of molecular medicine (Berlin, Germany) · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Corey N CunninghamDepartment of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI.
Kaiyu HeDepartment of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI.
Anoop ArunagiriDivision of Metabolism Endocrinology & Diabetes, University of Michigan Medical School, Ann Arbor, MI.
Adrienne W PatonResearch Centre for Infectious Diseases, Department of Molecular and Cellular Biology, University of Adelaide, Adelaide, Australia.
James C PatonResearch Centre for Infectious Diseases, Department of Molecular and Cellular Biology, University of Adelaide, Adelaide, Australia.
Peter ArvanCellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI btsai@umich.edu parvan@med.umich.edu.
Billy TsaiDepartment of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI btsai@umich.edu parvan@med.umich.edu.
University of Michigan–Ann Arbor · USUniversity of Adelaide · AU
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MCELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8MProinsulin Trafficking for Insulin BiosynthesisR01DK048280 · NIDDK · YESHIVA UNIVERSITY · PI ARVAN, PETER · 1994 to 2024
$10.5MSecretory Pathway Protein Degradation Maintains Insulin Biogenesis + SecretionR01DK111174 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARVAN, PETER, QI, LING · 2016 to 2024
$5.5MNIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK048280NIDDK NIH HHS R01 DK111174NIGMS NIH HHS T32 GM007315
Abstract
In heterozygous patients with a diabetic syndrome called mutant
Indexed as
AnimalsCell Line, TumorDiabetes MellitusEndoplasmic ReticulumEndoplasmic Reticulum-Associated DegradationGene Knockdown TechniquesGlycoproteinsHEK293 CellsHeterozygoteHSP70 Heat-Shock ProteinsHumansInsulinInsulin-Secreting CellsInsulin SecretionMolecular ChaperonesMutationglucose-regulated protein 170GlycoproteinsHSP70 Heat-Shock ProteinsInsulinMolecular ChaperonesProinsulin
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.