Evidence map›Paper›PMID 28028054›Full record

ArticleThe EMBO journal2017

Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.

Alexandra Stolz, Mateusz Putyrski, Ivana Kutle, Jessica Huber, Chunxin Wang, Viktória Major, Sachdev S Sidhu, Richard J Youle, Vladimir V Rogov, Volker Dötsch and 2 more

Abstract read
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandra StolzInstitute of Biochemistry II Goethe University, Frankfurt am Main, Germany.
Mateusz PutyrskiInstitute of Biochemistry II Goethe University, Frankfurt am Main, Germany.
Ivana KutleBuchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany.
Jessica HuberInstitute of Biophysical Chemistry, Goethe University, Frankfurt am Main, Germany.
Chunxin WangBiochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6015-6806
Viktória MajorInstitute of Biochemistry II Goethe University, Frankfurt am Main, Germany.
Sachdev S SidhuBanting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Richard J YouleBiochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Vladimir V RogovInstitute of Biophysical Chemistry, Goethe University, Frankfurt am Main, Germany.
Volker DötschInstitute of Biophysical Chemistry, Goethe University, Frankfurt am Main, Germany.
Andreas ErnstInstitute of Biochemistry II Goethe University, Frankfurt am Main, Germany ernst@biochem2.de dikic@biochem2.uni-frankfurt.de.ORCID 0000-0001-5122-5005
Ivan DikicInstitute of Biochemistry II Goethe University, Frankfurt am Main, Germany ernst@biochem2.de dikic@biochem2.uni-frankfurt.de.ORCID 0000-0001-8156-9511

Funding

Role of mitochondria in neurodegenerative diseasesZIANS003123 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI YOULE, RICHARD JAMES · 2011 to 2025
$28.8M
Mechanisms of AutophagyZIANS003127 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI YOULE, RICHARD JAMES · 2011 to 2025
$16.7M
6 · The paper itself

Abstract

Autophagy is a cellular surveillance pathway that balances metabolic and energy resources and transports specific cargos, including damaged mitochondria, other broken organelles, or pathogens for degradation to the lysosome. Central components of autophagosomal biogenesis are six members of the LC3 and GABARAP family of ubiquitin-like proteins (mATG8s). We used phage display to isolate peptides that possess

Indexed as

AutophagyAutophagy-Related Protein 8 FamilyBiosensing TechniquesCell LineFluorescenceHumansMitochondriaPeptide LibraryProtein BindingSalmonellaStaining and LabelingAutophagy-Related Protein 8 FamilyPeptide LibraryATG8immunofluorescenceLC3phage displayselective autophagy

Identifiers

PMID28028054
PMCPMC5437816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.