Evidence map›Paper›PMID 28028022›Full record

ArticleBlood2017

Multiple myeloma cells' capacity to decompose H

Sinto Sebastian, Yuan X Zhu, Esteban Braggio, Chang-Xin Shi, Sonali C Panchabhai, Scott A Van Wier, Greg J Ahmann, Marta Chesi, P Leif Bergsagel, A Keith Stewart and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  7. Review
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  9. Article
  10. Article
  11. HNanomaterials (Basel, Switzerland) · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Regulation of Ferroptosis Pathway by Ubiquitination.Frontiers in cell and developmental biology · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sinto SebastianDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
Yuan X ZhuDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
Esteban BraggioDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
Chang-Xin ShiDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
Sonali C PanchabhaiDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
Scott A Van WierDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
Greg J AhmannDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
Marta ChesiDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
P Leif BergsagelDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
A Keith StewartDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
Rafael FonsecaDivision of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ.
Mayo Clinic in Arizona · US

Funding

ECOG OPERATIONS OFFICE (IBCSG)U10CA021115 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI COMIS, ROBERT L · 1985 to 2013
$132.6M
Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Rafael Fonseca · 2015 to 2026
$25.5M
CHROMOSOMAL ABNORMALITIES IN MYELOMA AS DETECTED BY FISHR01CA083724 · NCI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI FONSECA, RAFAEL · 2000 to 2013
$4.0M
PQD2 Rational Combination of Standard Agents and Immunotherapy to Treat MyelomaR01CA190045 · NCI · MAYO CLINIC ARIZONA · PI CHESI, MARTA · 2014 to 2017
$1.4M
NCI NIH HHS P50 CA186781NCI NIH HHS R01 CA083724NCI NIH HHS R01 CA190045NCI NIH HHS U10 CA021115
6 · The paper itself

Abstract

Lenalidomide is an immunomodulatory drug (IMiDs) with clinical efficacy in multiple myeloma (MM) and other late B-cell neoplasms. Although cereblon (

Indexed as

Adaptor Proteins, Signal TransducingCell Line, TumorCell SurvivalEndoplasmic Reticulum StressHumansHydrogen PeroxideIkaros Transcription FactorImmunologic FactorsLenalidomideMultiple MyelomaOxidative StressPeptide HydrolasesPeroxidaseProteolysisThalidomideUbiquitin-Protein LigasesAdaptor Proteins, Signal TransducingCRBN protein, humanHydrogen PeroxideIkaros Transcription FactorIKZF1 protein, humanIKZF3 protein, humanImmunologic FactorsLenalidomidePeptide HydrolasesPeroxidaseThalidomideUbiquitin-Protein Ligases

Identifiers

PMID28028022
PMCPMC5324717
OpenAlexW2565642046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.