Evidence map›Paper›PMID 28027803›Full record

ReviewTrends in microbiology2017

Rules of Engagement: The Type VI Secretion System in Vibrio cholerae.

Avatar Joshi, Benjamin Kostiuk, Andrew Rogers, Jennifer Teschler, Stefan Pukatzki, Fitnat H Yildiz

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. TseCurrent research in microbial sciences · 2026
    Article
  5. Article
  6. Unveiling pathogenicity and resistance profiles of non-cholera Vibrio from an urban estuary.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  7. Review
  8. Decoding resistance in the age of T6SS warfare.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Modulation ofJournal of bacteriology · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Avatar JoshiDepartment of Microbiology and Environmental Toxicology, University of Santa Cruz, Santa Cruz, California, USA.
Benjamin KostiukDepartment of Medical Microbiology and Immunology, University of Alberta, Alberta, Canada.
Andrew RogersDepartment of Microbiology and Environmental Toxicology, University of Santa Cruz, Santa Cruz, California, USA.
Jennifer TeschlerDepartment of Microbiology and Environmental Toxicology, University of Santa Cruz, Santa Cruz, California, USA.
Stefan PukatzkiDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Fitnat H YildizDepartment of Microbiology and Environmental Toxicology, University of Santa Cruz, Santa Cruz, California, USA. Electronic address: fyildiz@ucsc.edu.

Funding

Vibrio cholerae c-diGMP signaling: Motile to biofilm transition and transmissionR01AI102584 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2013 to 2023
$6.5M
Vibrio cholerae biofilms: structure, function, regulation and role in infectionR01AI114261 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2014 to 2024
$5.0M
Vibrio cholerae c-diGMP signaling: motile to biofilm transition and transmissionR56AI102584 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2012 to 2012
$608k
CIHRNIAID NIH HHS R01 AI102584NIAID NIH HHS R01 AI114261NIAID NIH HHS R56 AI102584
6 · The paper itself

Abstract

Microbial species often exist in complex communities where they must avoid predation and compete for favorable niches. The type VI secretion system (T6SS) is a contact-dependent bacterial weapon that allows for direct killing of competitors through the translocation of proteinaceous toxins. Vibrio cholerae is a Gram-negative pathogen that can use its T6SS during antagonistic interactions with neighboring prokaryotic and eukaryotic competitors. The T6SS not only promotes V. cholerae's survival during its aquatic and host life cycles, but also influences its evolution by facilitating horizontal gene transfer. This review details the recent insights regarding the structure and function of the T6SS as well as the diverse signals and regulatory pathways that control its activation in V. cholerae.

Indexed as

AntibiosisBacterial ToxinsCholeraGene Transfer, HorizontalHumansQuorum SensingType VI Secretion SystemsVibrio choleraeBacterial ToxinsType VI Secretion Systemsfunctionregulationstructuretype VI secretion system (T6SS)Vibrio cholerae

Identifiers

PMID28027803
PMCPMC5365375

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.