Evidence map›Paper›PMID 28027790›Full record

Trial reportThe Journal of thoracic and cardiovascular surgery2017

The impact of red blood cell storage duration on tissue oxygenation in cardiac surgery.

Christopher P Stowell, Glenn Whitman, Suzanne Granger, Hernando Gomez, Susan F Assmann, Michael J Massey, Nathan I Shapiro, Marie E Steiner, Elliott Bennett-Guerrero

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of thoracic and cardiovascular surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01274390 (Impact of Blood Storage Duration on Physiologic Measures), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01274390 completednot on this map

Impact of Blood Storage Duration on Physiologic Measures: RECESS Ancillary Physiologic Study (RECAP)

TypeobservationalSponsorDuke UniversityRan2011 to 2014Enrolled390ConditionsCardiac Surgery, Erythrocyte Transfusion
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Christopher P StowellBlood Transfusion Service, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass. Electronic address: cstowell@partners.org.
Glenn WhitmanDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Md.
Suzanne GrangerNew England Research Institutes, Watertown, Mass.
Hernando GomezDepartment of Critical Care Medicine, Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, Pa.
Susan F AssmannNew England Research Institutes, Watertown, Mass.
Michael J MasseyCenter for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Mass.
Nathan I ShapiroCenter for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Mass; Harvard Medical School, Boston, Mass.
Marie E SteinerDepartment of Pediatrics, University of Minnesota, Minneapolis, Minn.
Elliott Bennett-GuerreroDepartment of Anesthesiology, Duke University Medical Center, Durham, NC.

Funding

Pittsburgh Career Development Program in Emergency Medicine ResearchK12HL109068 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CALLAWAY, CLIFTON W., YEALY, DONALD M · 2011 to 2015
$3.1M
Impact of Blood Storage Duration on Physiologic Measures: RECESS Ancillary StudyR01HL101382 · NHLBI · DUKE UNIVERSITY · PI BENNETT-GUERRERO, ELLIOTT, STOWELL, CHRISTOPHER PUTNAM · 2010 to 2013
$1.6M
NHLBI NIH HHS K12 HL109068NHLBI NIH HHS R01 HL101382
6 · The paper itself

Abstract

objectiveAlthough storage alters red blood cells, several recent, randomized trials found no differences in clinical outcomes between patients transfused with red blood cells stored for shorter versus longer periods of time. The objective of this study was to see whether storage impairs the in vivo ability of erythrocytes to traverse the microcirculation and deliver oxygen at the tissue level.

methodsA subset of subjects from a clinical trial of cardiac surgery patients randomized to receive transfusions of red blood cells stored ≤10 days or ≥21 days were assessed for thenar eminence and cerebral tissue hemoglobin oxygen saturation (S

resultsAmong 55 subjects, there was little change in the primary endpoint (thenar eminence S

conclusionsThere were no differences in thenar eminence or cerebral S

Indexed as

Cardiac Surgical ProceduresAgedAged, 80 and overBlood PreservationErythrocytesErythrocyte TransfusionFemaleFollow-Up StudiesHumansMaleMicrocirculationMiddle AgedOxygenProspective StudiesRegional Blood FlowSpectroscopy, Near-InfraredOxygenmicrocirculationRBC storagetissue oxygenationtransfusion

Identifiers

PMID28027790
PMCPMC5316299

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.