ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2017
Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population.
Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Causal relationship between serum uric acid and cardiovascular disease: A Mendelian randomization study.International journal of cardiology. Heart & vasculature · 2024Article
- Clinicopathological characteristics and associated factors of idiopathic membranous nephropathy with hyperuricemia: a single-centered cross-sectional study.International urology and nephrology · 2023Article
- Prevalence of Hyperuricemia and the Use of Allopurinol in Older Poles-Results from a Population-Based PolSenior Study.International journal of environmental research and public health · 2021Article
- Hyperuricemia and Its Associated Factors Among Adult Staff Members of the Ethiopian Public Health Institute, Ethiopia.International journal of general medicine · 2021Article
- Article
- Hypertriglyceridemia and hyperuricemia: a retrospective study of urban residents.Lipids in health and disease · 2019Article
- Article
- Hyperuricemia and Hypertension: Links and Risks.Integrated blood pressure control · 2019Review
- Physiology of Hyperuricemia and Urate-Lowering Treatments.Frontiers in medicine · 2018Review
- Febuxostat attenuates ER stress mediated kidney injury in a rat model of hyperuricemic nephropathy.Oncotarget · 2017Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveIn clinical practice, patient characteristics predicting resistant hypertension (RH) include higher blood pressure levels, left ventricular hypertrophy, older age, obesity, chronic kidney disease and diabetes. On the contrary little is known about the role of serum uric acid (SUA) as a risk factor for RH in subjects from general population. MATERIAL AND
methods580 elderly subjects aged ≥65 years were enrolled in the Risk Of Vascular complications Impact of Genetics in Old people (ROVIGO) study. RH was defined as the failure to maintain blood pressure values below 140mmHg (systolic) and 90mmHg (diastolic) despite therapeutic interventions that include appropriate lifestyle measures plus adherence to treatment with full doses of at least three antihypertensive drugs, including a diuretic. RH was confirmed using 24-h ambulatory blood pressure measurement. Hyperuricemic was defined as the subjects having SUA ≥6.8mg/dl or taking uricosuric drugs. Gender-specific odds ratio (OR) for RH was calculated by logistic regression analysis.
resultsThe prevalence of RH was 5.7% in the cohort and was higher in women (8.3%) than in men (3.0%, p<0.05). Independent of chronic kidney disease (OR 3.89, 95% confidence interval 1.49-10.1), hyperuricemia predicted resistant hypertension in women (odds ratio 3.11, 95% confidence intervals 1.06-9.1, p=0.03) but not in men.
conclusionsIn elderly women from the general population, an SUA value of ≥6.8mg/dl triples the risk of RH. SUA assessment should be recommended to better define the pattern of risk associated with RH.
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