ArticlePLoS neglected tropical diseases2016
Insecticide and Repellent Mixture Pour-On Protects Cattle against Animal Trypanosomosis.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Dendritic Mesoporous Silica Nanoparticle-Based Co-Delivery of a Repellent and an Insecticide for Management of the Asian Citrus Psyllid.Nanomaterials (Basel, Switzerland) · 2026Article
- Advances in veterinary drug and vaccine delivery: from conventional delivery methods to innovative transdermal approaches.Drug delivery and translational research · 2026Review
- Interventions for Neglected Diseases Caused by Kinetoplastid Parasites: A One Health Approach to Drug Discovery, Development, and Deployment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Impact of Cypermethrin persistence on stomoxyine abundance and Trypanosoma Vivax infection.Tropical animal health and production · 2024Article
- Animal trypanosomosis eliminated in a major livestock production region in Senegal following the eradication of a tsetse population.Parasite (Paris, France) · 2024Article
- Environmental impact of tsetse eradication in Senegal.Scientific reports · 2019Article
- Comparative insecticidal activity of cypermethrin and cypermethrin-mix applications against stomoxyine vectors.Tropical animal health and production · 2019Article
- Impact of an integrated control campaign on tsetse populations in Burkina Faso.Parasites & vectors · 2018Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAfrican animal trypanosomosis (AAT), transmitted by tsetse flies and tick-borne diseases are the main constraints to livestock production in sub-Saharan Africa. Vector control methods such as pour-on offer individual protection against ticks but not against tsetse so far, for which protection has always been communal, through a reduction of their density. The latter requires the treatment of a large part of the herd in a given landscape and is not instantaneous. METHODOLOGY/PRINCIPAL
findingsTwo prospective surveys were conducted to evaluate the efficacy and persistence of a pour-on formulation composed of cypermetrhin, chlorpyrifos, piperonyl butoxid and citronella (Vectoclor, CEVA Santé Animal). In experimental conditions, tsetse flies were exposed to treated and control cattle. Flies knockdown and engorgement rates were determined and the product persistence was assessed as the time for these parameters to drop below 50% (T50). T50 was 37 days (95%CI: [33-41] days) and 46 days (95%CI: [39-56] days) for the knockdown and engorgement rates respectively. In field conditions, two cattle herds were monitored following a case-control experimental design, in the Adamaoua region of Cameroon. One herd was treated once with Vectoclor pour-on (treated group) and the second used as a control group (not treated). Ticks infestation rate, trypanosomosis prevalence and packed-cell volume were measured over the two months following treatment. The treatment was highly effective against ticks with a complete elimination three days after application in the treated group. Trypanosomosis prevalence was also significantly reduced during the study (by 4, P<0.001) and PCV of the treated group increased significantly in the same time (P<0.001), contrary to the control group. CONCLUSIONS/SIGNIFICANCE: The protection of this new pour-on against tsetse bites and trypanosomosis is demonstrated here for the first time. Moreover, this insecticide and repellent mixture offer a longer persistence of the efficacy against both tsetse and ticks than similar products currently on the market. It offers a great new opportunity for an integrated AAT control strategy including the treatment of residual cases with trypanocides. It might also allow controlling the spread of resistance against these trypanocides.
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