ArticlePLoS pathogens2016
Scavenger Receptor C Mediates Phagocytosis of White Spot Syndrome Virus and Restricts Virus Proliferation in Shrimp.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Single-nucleus RNA sequencing illuminates a functional analog of lymphoid organ in crustacean.Journal of advanced research · 2026Article
- A unique echinoderm NLR triggers Vibrio phagocytosis by promoting microtubule severing to facilitate microfilament polymerization.The Journal of biological chemistry · 2026Article
- Cellular uptake of extracellular dsRNA is tissue-dependent in insects.BMC biology · 2026Article
- An invertebrate NLR recognizes viral nucleic acids and balances the antiviral signaling pathway through interaction with STING and Cyclophilin A.PLoS pathogens · 2025Article
- Class B scavenger receptor resists WSSV replication by recognizing the viral lipid molecule and promoting phagocytosis.Journal of virology · 2025Article
- Infection and intracellular transport of white spot syndrome virus require the ESCRT machinery in shrimp.Journal of virology · 2024Article
- Recognition of Arboviruses by the Mosquito Immune System.Biomolecules · 2023Review
- Scavenger receptor B2, a type III membrane pattern recognition receptor, senses LPS and activates the IMD pathway in crustaceans.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- N6-methyladenosine helps Apostichopus japonicus resist Vibrio splendidus infection by targeting coelomocyte autophagy via the AjULK-AjYTHDF/AjEEF-1α axis.Communications biology · 2023Article
- PcTrim prevents early infection with white spot syndrome virus by inhibiting AP1-induced endocytosis.Cell communication and signaling : CCS · 2023Article
- CgDM9CP-5-Integrin-MAPK Pathway Regulates the Production of CgIL-17s and Cgdefensins in the Pacific Oyster, Crassostrea gigas.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Sf-FGFR and Sf-SR-C Are Not the Receptors for Vip3Aa to Exert Insecticidal Toxicity inInsects · 2022Article
- Role of Cellular Receptors in the Innate Immune System of Crustaceans in Response to White Spot Syndrome Virus.Viruses · 2022Review
- Anti-lipopolysaccharide factor D from kuruma shrimp exhibits antiviral activity.Marine life science & technology · 2022Article
- Comparative transcriptomics reveals the immune dynamics during the molting cycle of swimming crabFrontiers in immunology · 2022Article
- Transcriptome analysis reveals immune and metabolic regulation effects ofFrontiers in immunology · 2022Article
- A unique NLRC4 receptor from echinoderms mediates Vibrio phagocytosis via rearrangement of the cytoskeleton and polymerization of F-actin.PLoS pathogens · 2021Article
- Identification of a Shrimp E3 Ubiquitin Ligase TRIM50-Like Involved in Restricting White Spot Syndrome Virus Proliferation by Its Mediated Autophagy and Ubiquitination.Frontiers in immunology · 2021Article
- Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry.Emerging microbes & infections · 2020Article
- White Spot Syndrome Virus Benefits from Endosomal Trafficking, Substantially Facilitated by a Valosin-Containing Protein, To Escape Autophagic Elimination and Propagate in the Crustacean Cherax quadricarinatus.Journal of virology · 2020Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scavenger receptors are an important class of pattern recognition receptors that play several important roles in host defense against pathogens. The class C scavenger receptors (SRCs) have only been identified in a few invertebrates, and their role in the immune response against viruses is seldom studied. In this study, we firstly identified an SRC from kuruma shrimp, Marsupenaeus japonicus, designated MjSRC, which was significantly upregulated after white spot syndrome virus (WSSV) challenge at the mRNA and protein levels in hemocytes. The quantity of WSSV increased in shrimp after knockdown of MjSRC, compared with the controls. Furthermore, overexpression of MjSRC led to enhanced WSSV elimination via phagocytosis by hemocytes. Pull-down and co-immunoprecipitation assays demonstrated the interaction between MjSRC and the WSSV envelope protein. Electron microscopy observation indicated that the colloidal gold-labeled extracellular domain of MjSRC was located on the outer surface of WSSV. MjSRC formed a trimer and was internalized into the cytoplasm after WSSV challenge, and the internalization was strongly inhibited after knockdown of Mjβ-arrestin2. Further studies found that Mjβ-arrestin2 interacted with the intracellular domain of MjSRC and induced the internalization of WSSV in a clathrin-dependent manner. WSSV were co-localized with lysosomes in hemocytes and the WSSV quantity in shrimp increased after injection of lysosome inhibitor, chloroquine. Collectively, this study demonstrated that MjSRC recognized WSSV via its extracellular domain and invoked hemocyte phagocytosis to restrict WSSV systemic infection. This is the first study to report an SRC as a pattern recognition receptor promoting phagocytosis of a virus.
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