Evidence map›Paper›PMID 28027279›Full record

ArticleThe Pediatric infectious disease journal2017

The Influence of the Route of Antibiotic Administration, Methicillin Susceptibility, Vancomycin Duration and Serum Trough Concentration on Outcomes of Pediatric Staphylococcus aureus Bacteremic Osteoarticular Infection.

J Chase McNeil, Sheldon L Kaplan, Jesus G Vallejo

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In one paragraph

Article in The Pediatric infectious disease journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Appropriate Antibiotic Duration in Pediatric Bone and Joint Infection: A Systematic Review.Journal of the Pediatric Orthopaedic Society of North America · 2023
    Article
  7. Intravenous versus Oral Step-Down for the Treatment ofPharmacy (Basel, Switzerland) · 2022
    Article
  8. Prediction of Adverse Outcomes in Pediatric Acute Hematogenous Osteomyelitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. The History of Antibiotic Treatment of Osteomyelitis.Open forum infectious diseases · 2019
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Use of Body Surface Area for Dosing of Vancomycin.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J Chase McNeilFrom the Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas.
Sheldon L Kaplan
Jesus G Vallejo
Apple (Israel) · IL

Funding

Staphylococcus aureus resistance to topical antimicrobial agents in childrenK23AI099159 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MCNEIL, JONATHON CHASE · 2013 to 2017
$821k
NIAID NIH HHS K23 AI099159
6 · The paper itself

Abstract

backgroundBacteremia is often one factor used in deciding the need for prolonged intravenous antimicrobial therapy in osteoarticular infections (OAIs). We examined treatment practices and outcomes of Staphylococcus aureus bacteremic osteoarticular infections (BOAIs) evaluated at Texas Children's Hospital.

methodsCases of acute hematogenous OAI in children with positive blood cultures for S. aureus at Texas Children's Hospital between 2011 and 2014 were reviewed. Orthopedic complications included chronic osteomyelitis, growth arrest, pathologic fracture, avascular necrosis and chronic dislocation. Acute kidney injury was defined as a doubling of the baseline creatinine.

resultsOne hundred and ninety-two cases of S. aureus OAI were identified with 102 cases of BOAI included [35 methicillin-resistant S. aureus (MRSA)]. Twenty-five patients were discharged home on oral antibiotics. Patients discharged on oral antibiotics had a shorter duration of fever, had a more rapid decline in C-reactive protein and were less likely to have MRSA. The frequency of orthopedic complications did not increase in patients who received early transition to oral antibiotics. For patients with MRSA bacteremia, the rates of complications between those who received ≥7 days versus <7 days of vancomycin did not differ. Vancomycin serum troughs >15 µg/mL were not associated with a decreased duration of fever, bacteremia or hospitalization, need for repeat operation or orthopedic complications but were associated with acute kidney injury.

conclusionsS. aureus BOAIs are associated with substantial morbidity. Early transition to oral therapy may be a safe option for select patients with S. aureus BOAI, including those due to MRSA. Prolonged courses of vancomycin and vancomycin troughs >15 μg/mL were not associated with improved outcomes for MRSA OAI.

Indexed as

Anti-Bacterial AgentsBacteremiaChildChild, PreschoolHumansMethicillin ResistanceMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsOsteomyelitisRetrospective StudiesStaphylococcal InfectionsTreatment OutcomeVancomycinAnti-Bacterial AgentsVancomycin

Identifiers

PMID28027279
PMCPMC5534171
OpenAlexW2561478310

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.