ArticlePlastic and reconstructive surgery2017
Cancer Risk after Fat Transfer: A Multicenter Case-Cohort Study.
Article in Plastic and reconstructive surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Postmastectomy Breast Reconstruction in Patients with Non-Metastatic Breast Cancer: A Systematic Review.Current oncology (Toronto, Ont.) · 2025Pooled it
- Adipocyte-derived LTB4 programs human NKG2AJournal for immunotherapy of cancer · 2026Article
- Autologous fat grafting and injectable fillers for post-reconstructive breast remodelling: A systematic review and quantitative synthesis.JPRAS open · 2026Review
- Adipose-Derived Stem Cell-Enhanced versus Conventional Fat Grafting for Breast Reconstruction: A Systematic Review and Meta-Analysis.Plastic and reconstructive surgery · 2026Article
- Immediate Oncoplastic Breast Reconstruction with Fat Grafting: Preliminary Radiological, Aesthetic, and Patient Satisfaction Outcomes.Aesthetic plastic surgery · 2025Article
- The Landscape of Research on Autologous Fat Grafting for Breast Reconstruction.Aesthetic plastic surgery · 2025Article
- Autologous Fat Grafting (AFG): A Systematic Review to Evaluate Oncological Safety in Breast Cancer Patients.Journal of clinical medicine · 2024Review
- Endoscopic mastectomy followed by immediate breast reconstruction with fat grafting for breast cancer.Breast cancer (Tokyo, Japan) · 2024Article
- Breast fat grafting and cancer: a systematic review of the science behind enhancements and concerns.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2024Review
- Recent advances in surgical techniques for breast reconstruction.International journal of clinical oncology · 2023Review
- Review of Autologous Fat Grafting in Postmastectomy Reconstruction Patients: Nonroutine Diagnostics and Oncologic Safety.Plastic and reconstructive surgery. Global open · 2022Article
- The Crosstalk Between Adipose-Derived Stem or Stromal Cells (ASC) and Cancer Cells and ASC-Mediated Effects on Cancer Formation and Progression-ASCs: Safety Hazard or Harmless Source of Tropism?Stem cells translational medicine · 2022Review
- Autologous fat grafting for breast reconstruction after breast cancer: a 12-year experience.Archives of gynecology and obstetrics · 2022Article
- TFEB, SIRT1, CARM1, Beclin-1 expression and PITX2 methylation in breast cancer chemoresistance: a retrospective study.BMC cancer · 2021Observational
- Effect of Breast Cancer and Adjuvant Therapy on Adipose-Derived Stromal Cells: Implications for the Role of ADSCs in Regenerative Strategies for Breast Reconstruction.Stem cell reviews and reports · 2021Review
- Analysis of oncological safety of autologous fat grafting after immediate breast reconstruction.Gland surgery · 2021Article
- Adipose tissue-derived stem cells in breast reconstruction: a brief review on biology and translation.Stem cell research & therapy · 2021Review
- Autologous fat grafting in breast reconstruction: implications for follow-up and surveillance.Gland surgery · 2021Review
- Autologous Fat Grafting Does Not Increase Risk of Oncologic Recurrence in the Reconstructed Breast.Annals of plastic surgery · 2020Article
- The Classification and Surgical Treatment of Adult Acquired Buried Penis Syndrome: A Call for Data and Collaboration.Aesthetic surgery journal · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundFat transfer is an increasingly popular method for refining postmastectomy breast reconstructions. However, concern persists that fat transfer may promote disease recurrence. Adipocytes are derived from adipose-derived stem cells and express adipocytokines that can facilitate active breast cancer cells in laboratory models. The authors sought to evaluate the association between fat transfer to the reconstructed breast and cancer recurrence in patients diagnosed with local or regional invasive breast cancers.
methodsA multicenter, case-cohort study was performed. Eligible patients from four centers (Memorial Sloan Kettering, M. D. Anderson Cancer Center, Alvin J. Siteman Cancer Center, and the University of Chicago) were identified by each site's institutional tumor registry or cancer data warehouse. Eligibility criteria were as follows: mastectomy with immediate breast reconstruction between 2006 and 2011, age older than 21 years, female sex, and incident diagnosis of invasive ductal carcinoma (stage I, II, or III). Cases consisted of all recurrences during the study period, and controls consisted of a 30 percent random sample of the study population. Cox proportional hazards regression was used to evaluate for association between fat transfer and time to recurrence in bivariate and multivariate models.
resultsThe time to disease recurrence unadjusted hazard ratio for fat transfer was 0.99 (95 percent CI, 0.56 to 1.7). After adjustment for age, body mass index, stage, HER2/Neu receptor status, and estrogen receptor status, the hazard ratio was 0.97 (95 percent CI, 0.54 to 1.8).
conclusionIn this population of breast cancer patients who had mastectomy with immediate reconstruction, fat transfer was not associated with a higher risk of cancer recurrence. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.
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