ArticleEnvironmental science & technology2017
LC- and GC-QTOF-MS as Complementary Tools for a Comprehensive Micropollutant Analysis in Aquatic Systems.
Article in Environmental science & technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- QTOF and Orbitrap Technologies in Modern Pesticide Analysis: Applications in Residue Detection and Degradation Pathway Elucidation.Journal of analytical methods in chemistry · 2026Review
- Nontargeted Analysis of Surface and Groundwaters Impacted by Historic PFAS Waste Sites.Environmental science & technology · 2025Article
- Household-Level Variability of Nontarget Analytical Results for Drinking Water Provides a Tool for Uncovering Constituents Introduced by Distribution System Components.Environmental science & technology · 2025Article
- Comprehensive Nontargeted Analysis of Drinking Water Supplies to Identify Chemicals Associated with Estrogen Receptor Agonism or Present in Regions of Elevated Breast Cancer Occurrence.Environmental science & technology · 2025Article
- Aqueous exposure to a pyrethroid pesticide results in behavioural effects in early life stage sturgeon.Conservation physiology · 2025Article
- Effect-Directed Analysis Combined with Nontarget Screening to Identify Unmonitored Toxic Substances in the Environment.Environmental science & technology · 2023Review
- Leached Compounds from Smoked Cigarettes and Their Potential for Bioaccumulation in Rainbow Trout (Chemical research in toxicology · 2023Article
- Development and application of an in-house library and workflow for gas chromatography-electron ionization-accurate-mass/high-resolution mass spectrometry screening of environmental samples.Analytical and bioanalytical chemistry · 2022Article
- Article
- Using Estrogenic Activity and Nontargeted Chemical Analysis to Identify Contaminants in Sewage Sludge.Environmental science & technology · 2021Article
- Identifying Toxicologically Significant Compounds in Urban Wildfire Ash UsingEnvironmental science & technology · 2021Article
- From Pesticides to Per- and Polyfluoroalkyl Substances: An Evaluation of Recent Targeted and Untargeted Mass Spectrometry Methods for Xenobiotics.Analytical chemistry · 2021Review
- Screening for More than 1,000 Pesticides and Environmental Contaminants in Cannabis by GC/Q-TOF.Medical cannabis and cannabinoids · 2020Article
- Article
- Article
- Bi-Directional Learning: Identifying Contaminants on the Yurok Indian Reservation.International journal of environmental research and public health · 2019Article
- New Approach Methodologies for Exposure Science.Current opinion in toxicology · 2019Article
- Analyzing a broader spectrum of endocrine active organic contaminants in sewage sludge with high resolution LC-QTOF-MS suspect screening and QSAR toxicity prediction.Environmental science. Processes & impacts · 2019Article
- Exposure Assessment For Air-To-Skin Uptake of Semivolatile Organic Compounds (SVOCs) Indoors.Environmental science & technology · 2019Article
- Developmental exposure to environmentally relevant concentrations of bifenthrin alters transcription of mTOR and ryanodine receptor-dependent signaling molecules and impairs predator avoidance behavior across early life stages in inland silversides (Menidia beryllina).Aquatic toxicology (Amsterdam, Netherlands) · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Efficient strategies are required to implement comprehensive suspect screening methods using high-resolution mass spectrometry within environmental monitoring campaigns. In this study, both liquid and gas chromatography time-of-flight mass spectrometry (LC-QTOF-MS and GC-QTOF-MS) were used to screen for >5000 target and suspect compounds in the Sacramento-San Joaquin River Delta in Northern California. LC-QTOF-MS data were acquired in All-Ions fragmentation mode in both positive and negative electrospray ionization (ESI). LC suspects were identified using two accurate mass LC-QTOF-MS/MS libraries containing pesticides, pharmaceuticals, and other environmental contaminants and a custom exact mass database with predicted transformation products (TPs). The additional fragment information from the All-Ions acquisition improved the confirmation of the compound identity, with a low false positive rate (9%). Overall, 25 targets, 73 suspects, and 5 TPs were detected. GC-QTOF-MS extracts were run in negative chemical ionization (NCI) for 21 targets (mainly pyrethroids) at sub-ng/L levels. For suspect screening, extracts were rerun in electron ionization (EI) mode with a retention time locked method using a GC-QTOF-MS pesticide library (containing exact mass fragments and retention times). Sixteen targets and 42 suspects were detected, of which 12 and 17, respectively, were not identified by LC-ESI-QTOF-MS. The results highlight the importance of analyzing water samples using multiple separation techniques and in multiple ionization modes to obtain a comprehensive chemical contaminant profile. The investigated river delta experiences significant pesticide inputs, leading to environmentally critical concentrations during rain events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.