Evidence map›Paper›PMID 28026901›Full record

Trial reportObesity (Silver Spring, Md.)2017

The effect of exercise on body composition and bone mineral density in breast cancer survivors taking aromatase inhibitors.

Gwendolyn A Thomas, Brenda Cartmel, Maura Harrigan, Martha Fiellin, Scott Capozza, Yang Zhou, Elizabeth Ercolano, Cary P Gross, Dawn Hershman, Jennifer Ligibel and 4 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 12 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 12 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Pooled it
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  4. The effects of exercise on the bone health of people with cancer: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Pooled it
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  8. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
    Pooled it
  9. The effect of exercise on aromatase inhibitor-induced musculoskeletal symptoms in breast cancer survivors :a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
  10. Pooled it
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  12. The effect of exercise on bone mineral density in adult cancer survivors: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Pooled it
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  14. Aerobic exercise and aromatase inhibitor-associated musculoskeletal symptoms: results of a randomized clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Gwendolyn A ThomasDepartment of Exercise Science, Syracuse University, Syracuse, New York, USA.
Brenda CartmelYale Cancer Center, Yale University, New Haven, Connecticut, USA.
Maura HarriganYale Cancer Center, Yale University, New Haven, Connecticut, USA.
Martha FiellinYale Cancer Center, Yale University, New Haven, Connecticut, USA.
Scott CapozzaYale Cancer Center, Yale University, New Haven, Connecticut, USA.
Yang ZhouYale Cancer Center, Yale University, New Haven, Connecticut, USA.
Elizabeth ErcolanoYale Cancer Center, Yale University, New Haven, Connecticut, USA.
Cary P GrossYale Cancer Center, Yale University, New Haven, Connecticut, USA.
Dawn HershmanColumbia University, New York, New York, USA.
Jennifer LigibelDana Farber Cancer Institute, Boston, Massachusetts, USA.
Kathryn SchmitzPennsylvania State University, Hershey, Pennsylvania, USA.
Fang-Yong LiYale Cancer Center, Yale University, New Haven, Connecticut, USA.
Tara SanftYale Cancer Center, Yale University, New Haven, Connecticut, USA.
Melinda L IrwinYale Cancer Center, Yale University, New Haven, Connecticut, USA.
Yale Cancer Center · USYale University · USColumbia University · USDana-Farber Cancer Institute · USPennsylvania State University · USSyracuse University · US

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
RCT of exercise on aromatase inhibitor side effects in breast cancer survivorsR01CA132931 · NCI · YALE UNIVERSITY · PI IRWIN, MELINDA L · 2009 to 2012
$2.4M
NCATS NIH HHS UL1 TR000142NCI NIH HHS P30 CA016359NCI NIH HHS R01 CA132931
6 · The paper itself

Abstract

objectiveThis study examined the effect of 12 months of aerobic and resistance exercise versus usual care on changes in body composition in postmenopausal breast cancer survivors taking aromatase inhibitors (AIs).

methodsThe Hormones and Physical Exercise study enrolled 121 breast cancer survivors and randomized them to either supervised twice-weekly resistance exercise training and 150 min/wk of aerobic exercise (N = 61) or a usual care (N = 60) group. Dual-energy X-ray absorptiometry scans were conducted at baseline, 6 months, and 12 months to assess changes in body mass index, percent body fat, lean body mass, and bone mineral density.

resultsAt 12 months, the exercise group relative to the usual care group had a significant increase in lean body mass (0.32 vs. -0.88 kg, P = 0.03), a decrease in percent body fat (-1.4% vs. 0.48%, P = 0.03), and a decrease in body mass index (-0.73 vs. 0.17 kg/m

conclusionsA combined resistance and aerobic exercise intervention improved body composition in breast cancer survivors taking AIs. Exercise interventions may help to mitigate the negative side effects of AIs and improve health outcomes in breast cancer survivors.

Indexed as

SurvivorsAbsorptiometry, PhotonAgedAromatase InhibitorsBody CompositionBone DensityBreast NeoplasmsExerciseFemaleHumansMiddle AgedResistance TrainingAromatase Inhibitors

Identifiers

PMID28026901
PMCPMC5450163
OpenAlexW2565372774

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.