ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2017
Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- "True" Helicobacter pylori infection and non-cardia gastric cancer: A pooled analysis within the Stomach Cancer Pooling (StoP) Project.Helicobacter · 2022Pooled it
- Prevalence ofFrontiers in oncology · 2022Pooled it
- Clinical Characteristics of Patients With Previous Helicobacter pylori Infection-Induced Atrophic Gastritis.Cureus · 2024Article
- Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-naïve patients.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Exploring quality indicators for the detection of Helicobacter pylori-naïve gastric cancer: a cross-sectional nationwide survey.Clinical endoscopy · 2023Article
- Gastric Cancer Screening in Japan: A Narrative Review.Journal of clinical medicine · 2022Review
- Impact of socioeconomic status and sibling number on the prevalence ofNagoya journal of medical science · 2022Article
- Intestinal-type gastric dysplasia in Helicobacter pylori-naïve patients.Virchows Archiv : an international journal of pathology · 2022Article
- Sporadic foveolar-type gastric adenoma with a raspberry-like appearance in Helicobacter pylori-naïve patients.Virchows Archiv : an international journal of pathology · 2021Article
- Pepsinogen and Serum IgG Detection Is a Valuable Diagnostic Method forDiagnostics (Basel, Switzerland) · 2021Article
- Characteristics and Early Diagnosis of Gastric Cancer Discovered afterGut and liver · 2021Review
- BBOX1-AS1 Accelerates Gastric Cancer Proliferation by Sponging miR-3940-3p to Upregulate BIRC5 Expression.Digestive diseases and sciences · 2021Article
- Synchronous duodenal mucosa-associated lymphoid tissue lymphoma and gastric cancer.Clinical journal of gastroenterology · 2021Article
- miR-299-3p suppresses cell progression and induces apoptosis by downregulating PAX3 in gastric cancer.Open life sciences · 2021Article
- Classifying risk level of gastric cancer: Evaluation of questionnaire-based prediction model.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2020Article
- Clinical and genomic characteristics of mucosal signet-ring cell carcinoma in Helicobacter pylori-uninfected stomach.BMC gastroenterology · 2020Article
- Usefulness and Limitations of a Serum Screening System to Predict the Risk of Gastric Cancer.Internal medicine (Tokyo, Japan) · 2020Article
- Previous Helicobacter pylori infection-induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication.Helicobacter · 2020Review
- ABC Classification Is Less Useful for Older Koreans Born before 1960.Gut and liver · 2019Observational
- Gastric foveolar-type adenomas endoscopically showing a raspberry-like appearance in theEndoscopy international open · 2019Article
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Authors and funding
17 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimThe serological risk prediction system combines the pepsinogen test and anti-Helicobacter pylori (H. pylori) antibody determination. In this system, chronic atrophic gastritis (CAG) is diagnosed using the pepsinogen test. Patients who are H. pylori negative and pepsinogen negative are classified into group A, are assumed to be H. pylori uninfected, and are at an extremely low risk for gastric cancer. However, gastric cancers are detected in this group. The aim of this study is to clarify the clinicopathological status of group A patients with gastric cancer.
methodsA total of 109 gastric cancer patients classified as group A were enrolled in a multicenter study. Group A patients were divided into two subgroups: group AN (H. pylori uninfected) and group AP (H. pylori infected). They were compared to 183 H. pylori-infected gastric cancer patients who were not in group A.
resultsOf the 109 patients, only 7 were classified as group AN; the other 102 were classified as group AP. The clinicopathological features of group AP included older age, predominantly differentiated type cancer, endoscopically visualized CAG, and pepsinogen (PG) I/II ratio lower than that of group AN. In group AN, the depressed type was dominant, and the PG I/II ratio was higher than in those gastric cancer patients who were infected with H. pylori.
conclusionPatients in group AP had CAG, and their gastric cancers were similar to those of H. pylori-eradicated patients. Concerning the recent ABC classification system, advanced decision criteria should be proposed to decrease the false-negative evaluation of gastric cancer risk.
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