Evidence map›Paper›PMID 28025584›Full record

ArticleLeukemia2017

Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma.

M I da Silva Filho, A Försti, N Weinhold, I Meziane, C Campo, S Huhn, J Nickel, P Hoffmann, M M Nöthen, K-H Jöckel and 16 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Leukemia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The molecular landscape of AL amyloidosis.British journal of haematology · 2025
    Review
  4. Subepithelial Lesions of the Ocular Surface: A Review.Current ophthalmology reports · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Light Chain Amyloidosis.Mediterranean journal of hematology and infectious diseases · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 9 institutions in 6 countries.

M I da Silva FilhoDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
A FörstiDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
N WeinholdDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
I MezianeDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
C CampoDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
S HuhnDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
J NickelDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
P HoffmannInstitute of Human Genetics, University of Bonn, Bonn, Germany.
M M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
K-H JöckelInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Germany.
S LandiDepartment of Biology, University of Pisa, Pisa, Italy.
J S MitchellDivision of Genetics and Epidemiology, The Institute of Cancer Research, Surrey, UK.
D JohnsonDivision of Molecular Pathology, The Institute of Cancer Research, Surrey, UK.ORCID 0000-0003-0887-3343
G J MorganMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
R HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, Surrey, UK.
H GoldschmidtDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
A JauchInstitute of Human Genetics, University of Heidelberg, Heidelberg, Germany.
P MilaniDepartment of Molecular Medicine, Amyloidosis Research and Treatment Center, Foundation 'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo', University of Pavia, Pavia, Italy.
G MerliniDepartment of Molecular Medicine, Amyloidosis Research and Treatment Center, Foundation 'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo', University of Pavia, Pavia, Italy.
D RowcienoNational Amyloidosis Centre, University College London Medical School, London UK.
P HawkinsNational Amyloidosis Centre, University College London Medical School, London UK.
U HegenbartDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
G PalladiniDepartment of Molecular Medicine, Amyloidosis Research and Treatment Center, Foundation 'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo', University of Pavia, Pavia, Italy.ORCID 0000-0001-5994-5138
A WechalekarNational Amyloidosis Centre, University College London Medical School, London UK.
S O SchönlandDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
K HemminkiDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Heidelberg University · DEGerman Cancer Research Center · DEAmyloidosis Foundation · USInstitute of Cancer Research · GBUniversity of Pavia · ITUniversity of Bonn · DEUniversity of Arkansas for Medical Sciences · USUniversity of Duisburg-Essen · DEUniversity of Pisa · IT

Funding

Cancer Research UK C1298/A8362
6 · The paper itself

Abstract

Immunoglobulin light chain (AL) amyloidosis is characterized by tissue deposition of amyloid fibers derived from immunoglobulin light chain. AL amyloidosis and multiple myeloma (MM) originate from monoclonal gammopathy of undetermined significance. We wanted to characterize germline susceptibility to AL amyloidosis using a genome-wide association study (GWAS) on 1229 AL amyloidosis patients from Germany, UK and Italy, and 7526 healthy local controls. For comparison with MM, recent GWAS data on 3790 cases were used. For AL amyloidosis, single nucleotide polymorphisms (SNPs) at 10 loci showed evidence of an association at P<10

Indexed as

Genome-Wide Association StudyAdultAgedAged, 80 and overAmyloidosisCyclin D1FemaleGenetic Predisposition to DiseaseHumansImmunoglobulin Light ChainsMaleMiddle AgedMultiple MyelomaPolymorphism, Single NucleotideCyclin D1Immunoglobulin Light Chains

Identifiers

PMID28025584
OpenAlexW2562786298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.