ReviewThe American journal of case reports2016
Diagnosis and Treatment of Pythium Insidiosum Corneal Ulcer in a Chinese Child: A Case Report and Literature Review.
Review in The American journal of case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Worldwide distribution of human pythosis and biological characteristics of aFrontiers in medicine · 2025Article
- Clinical Features, Microbiological Characteristics, and Drug Sensitivity Analysis of Rare Human Spinal Pythiosis Strain.Journal of fungi (Basel, Switzerland) · 2024Article
- Outcomes of Pythium keratitis: a meta-analysis of individual patient data.Current ophthalmology reports · 2022Article
- Pythium insidiosum Keratitis: Past, Present, and Future.Ophthalmology and therapy · 2022Review
- Review
- Pythium insidiosum keratitis reported in China, raising the alertness to this fungus-like infection: a case series.Journal of medical case reports · 2021Article
- History and Perspective of Immunotherapy for Pythiosis.Vaccines · 2021Review
- Retrospective multifactorial analysis ofIndian journal of ophthalmology · 2021Review
- Clinical Outcomes of Radical Surgery and Antimicrobial Agents in Vascular Pythiosis: A Multicenter Prospective Study.Journal of fungi (Basel, Switzerland) · 2021Article
- Clinical Characteristics, Histopathology, and Treatment Outcomes ofClinical ophthalmology (Auckland, N.Z.) · 2021Article
- Human Pythiosis: Emergence of Fungal-Like Organism.Mycopathologia · 2020Review
- Review
- Article
- Successful medical management ofAmerican journal of ophthalmology case reports · 2019Article
- Pythium keratitis in South India: Incidence, clinical profile, management, and treatment recommendation.Indian journal of ophthalmology · 2019Article
- Successful management of pediatricOman journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Pythium insidiosum keratitis is a rare but sight-threatening disease with a high morbidity rate. It can be misdiagnosed as fungal keratitis in clinic settings. We report a case of severe Pythium insidiosum keratitis in a Chinese child, treated with combined approaches. CASE REPORT A 7-year-old boy from Hainan province in the south of China developed a suppurative corneal ulcer after being in a forest. A mass of hyphae was detected by confocal imaging in vivo, fungal smear test, and histochemical examination. Treatment with Natamycin, fluconazole, and Voriconazole for 1 month was unsuccessful, and a penetrating keratoplasty with anterior vitrectomy was performed. The infection reappeared 1 day after surgery, immediately after which anterior chamber irrigation with 0.02% Fluconazole and amphotericin B solution was performed. Finally, the globe was saved and there was no further recurrent infection. A cultured mycelial organism, which was hard to identify by biomorphology, was confirmed by PCR to be Pythium insidiosum. The zoospores were observed in water environments. The imaging characteristics of P. insidiosum in confocal microscopy are described herein. CONCLUSIONS This is the first case of Pythium insidiosum keratitis reported in China. It can be misdiagnosed as fungal keratitis in the clinic. Improving the awareness of clinicians, promoting early diagnosis, and a multidisciplinary approach, especially early surgery, improve the prognosis.
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