ArticleBrain sciences2016
Impact of Spinal Manipulation on Cortical Drive to Upper and Lower Limb Muscles.
Article in Brain sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Unravelling functional neurology: does spinal manipulation have an effect on the brain? - a systematic literature review.Chiropractic & manual therapies · 2019Pooled it
- Immediate clinical and neuromechanical effects of cervical spine manipulation compared to cervical spine mobilization among individuals with chronic neck pain: a randomized mechanistic cross-over trial.Chiropractic & manual therapies · 2026Trial
- Trial
- A randomized controlled trial comparing different sites of high-velocity low amplitude thrust on sensorimotor integration parameters.Scientific reports · 2024Trial
- Immediate impact of extremity manipulation on dual task performance: a randomized, crossover clinical trial.Chiropractic & manual therapies · 2021Trial
- Effects of spinal manipulative therapy biomechanical parameters on clinical and biomechanical outcomes of participants with chronic thoracic pain: a randomized controlled experimental trial.BMC musculoskeletal disorders · 2019Trial
- The effects of a single session of spinal manipulation on strength and cortical drive in athletes.European journal of applied physiology · 2018Trial
- Neurophysiological Response of Spinal Mobilization and Manipulation in Individuals With and Without Musculoskeletal Spine Disorders: A Scoping Review.The European journal of neuroscience · 2026Article
- Effects of High-Velocity Elbow Manipulation on Forearm Muscle Electromyographic Recovery in Karting Drivers: A Randomized Within-Participant Sham-Controlled Trial.Journal of clinical medicine · 2026Article
- Technologies to investigate the mechanisms of force-based manipulations: a narrative methods review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Neuromuscular Response to High-Velocity, Low-Amplitude Spinal Manipulation-An Overview.Medicina (Kaunas, Lithuania) · 2025Review
- Known-Group Validity and Sensitivity to Change in the Sensory-Motor Dysfunction Questionnaire in Individuals with Neck Pain: A Pilot Study.Brain sciences · 2024Article
- Case report: Morphological changes evident after manual therapy in two cases of late-diagnosed developmental dysplasia of the hip.Frontiers in pediatrics · 2022Article
- Immediate effect of lower extremity joint manipulation on a lower extremity somatosensory illusion: a randomized, controlled crossover clinical pilot study.Frontiers in human neuroscience · 2022Article
- The contemporary model of vertebral column joint dysfunction and impact of high-velocity, low-amplitude controlled vertebral thrusts on neuromuscular function.European journal of applied physiology · 2021Review
- Impact of a Carbohydrate Mouth Rinse on Corticomotor Excitability after Mental Fatigue in Healthy College-Aged Subjects.Brain sciences · 2021Article
- The Potential Mechanisms of High-Velocity, Low-Amplitude, Controlled Vertebral Thrusts on Neuroimmune Function: A Narrative Review.Medicina (Kaunas, Lithuania) · 2021Review
- The Effects of 4 Weeks of Chiropractic Spinal Adjustments on Motor Function in People with Stroke: A Randomized Controlled Trial.Brain sciences · 2021Article
- The Effects of Spinal Manipulation on Motor Unit Behavior.Brain sciences · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates whether spinal manipulation leads to changes in motor control by measuring the recruitment pattern of motor units in both an upper and lower limb muscle and to see whether such changes may at least in part occur at the cortical level by recording movement related cortical potential (MRCP) amplitudes. In experiment one, transcranial magnetic stimulation input-output (TMS I/O) curves for an upper limb muscle (abductor pollicus brevis; APB) were recorded, along with F waves before and after either spinal manipulation or a control intervention for the same subjects on two different days. During two separate days, lower limb TMS I/O curves and MRCPs were recorded from tibialis anterior muscle (TA) pre and post spinal manipulation. Dependent measures were compared with repeated measures analysis of variance, with
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.