ArticleInternational journal of molecular sciences2016
Analysis to Estimate Genetic Variations in the Idarubicin-Resistant Derivative MOLT-3.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 40 citations in OpenAlex.
- The development of cancers research based on mitochondrial heat shock protein 90.Frontiers in oncology · 2023Review
- RNA-seq and Mitochondrial DNA Analysis of Adrenal Gland Metastatic Tissue in a Patient with Renal Cell Carcinoma.Biology · 2022Article
- Examination of gender differences in patients with takotsubo syndrome according to left ventricular biopsy: two case reports.Journal of medical case reports · 2021Article
- Analysis of Candidate Idarubicin Drug Resistance Genes in MOLT-3 Cells Using Exome Nuclear DNA.Genes · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
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Abstract
Gene alterations are a well-established mechanism leading to drug resistance in acute leukemia cells. A full understanding of the mechanisms of drug resistance in these cells will facilitate more effective chemotherapy. In this study, we investigated the mechanism(s) of drug resistance in the human acute leukemia cell line MOLT-3 and its idarubicin-resistant derivative MOLT-3/IDR through complete mitochondrial and nuclear DNA analyses. We identified genetic differences between these two cell lines. The ND3 mutation site (p.Thr61Ile) in the mitochondrial DNA sequence was unique to MOLT-3/IDR cells. Moreover, we identified five candidate genes harboring genetic alterations, including
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