ArticleHuman molecular genetics2017
Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations.
Open access · bronzeAbstract read
In one paragraph
Article in Human molecular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 6 pooled it
2.9field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 6 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Predictive performance of risk prediction models for lung cancer incidence in Western and Asian countries: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Association of rs401681 (C > T) and rs402710 (C > T) polymorphisms in the CLPTM1L region with risk of lung cancer: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- The impact of EGFR T790M mutation status following the development of Osimertinib resistance on the efficacy of Osimertinib in non-small cell lung cancer: A meta-analysis.The clinical respiratory journal · 2024Pooled it
- Ethnicity-specific association between TERT rs2736100 (A > C) polymorphism and lung cancer risk: a comprehensive meta-analysis.Scientific reports · 2023Pooled it
- Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.Nature communications · 2023Pooled it
- Potential genetic modifiers for somatic EGFR mutation in lung cancer: a meta-analysis and literature review.BMC cancer · 2019Pooled it
- Sex-specific associations of the bilirubin-to-albumin ratio with lung cancer risk: evidence from Cox regression and causal survival forest analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Prevalence and Clinical Implications of Somatic and Germline EGFR Mutations in Patients with Non-Small-Cell Lung Cancer.Cancers · 2026Review
- DCBLD1 Promotes Lung Tumorigenesis by Inhibiting PTP1B Dephosphorylation of EGFR.International journal of biological sciences · 2026Article
- Stratifying lung adenocarcinoma risk with multi-ancestry polygenic risk scores in East Asian never-smokers.Journal of the National Cancer Institute · 2025Article
- Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers.medRxiv : the preprint server for health sciences · 2025Article
- Image harmonization and de-harmonization based on singular value decomposition (SVD) in medical domain.Quantitative imaging in medicine and surgery · 2025Article
- An online explainable ensemble machine learning model for predicting epidermal growth factor receptor mutation status in lung adenocarcinoma.Translational lung cancer research · 2025Article
- Potential Influence ofInternational journal of molecular sciences · 2025Article
- Polygenic Risk Score and Lung Adenocarcinoma Risk Among Never-Smokers by EGFR Mutation Status: A Brief Report.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025Article
- Enhancing disease risk gene discovery by integrating transcription factor-linked trans-variants into transcriptome-wide association analyses.Nucleic acids research · 2025Article
- Early-onset lung cancer in Asia: a narrative review.Frontiers in oncology · 2025Review
- Discriminating bronchiolar adenoma from peripheral lung cancer by thin-section computed tomography (CT): a 2-center study.Quantitative imaging in medicine and surgery · 2024Article
- GWAS advancements to investigate disease associations and biological mechanisms.Clinical and translational discovery · 2024Article
- Age at lung cancer diagnosis in females versus males who never smoke by race and ethnicity.British journal of cancer · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
186 authors at 20 institutions in 9 countries.
Wei Jie SeowDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Keitaro MatsuoDivision of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
Chao Agnes HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Kouya ShiraishiDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Minsun SongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Hee Nam KimDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Maria Pik WongDepartment of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
Yun-Chul HongDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
H Dean HosgoodDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Zhaoming WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
I-Shou ChangNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Jiu-Cun WangMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Margaret TuckerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Hu WeiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Tetsuya MitsudomiDivision of Thoracic Surgery, Kinki University School of Medicine, Sayama, Japan.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Jin Hee KimDepartment of Integrative Bioscience & Biotechnology, Sejong University, Seoul, Republic of Korea.
Baosen ZhouDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Min-Ho ShinDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Lap Ping ChungDepartment of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
She-Juan AnGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.
Ping WangDepartment of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People's Republic of China.
Hong ZhengDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Yasushi YatabeDepartment of Pathology and Molecular Diagnostics, Aichi Cancer Center Central Hospital, Nagoya, Japan.
Xu-Chao ZhangGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.
Young Tae KimDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Young-Chul KimLung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasun-eup, Republic of Korea.
Bryan A BassigDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jiang ChangDepartment of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
James Chung Man HoDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong.
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Michiaki KuboLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
Yataro DaigoCenter for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Hidemi ItoDivision of Epidemiology & Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Yukihide MomozawaLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
Kyota AshikawaLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Takayuki HondaDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Hiromi SakamotoDivision of Genetics, National Cancer Center Research Institute, Tokyo, Japan.
Hideo KunitohDepartment of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan.
Koji TsutaDepartment of Pathology, National Cancer Center Hospital, Tokyo, Japan.
Shun-Ichi WatanabeDivision of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
Hiroshi NokiharaDepartment of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Yohei MiyagiMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Kanagawa, Japan.
Haruhiko NakayamaDepartment of Thoracic Surgery, Kanagawa Cancer Center, Kanagawa, Japan.
Shingo MatsumotoDivision of Translational Research, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Chiba, Japan.
Masahiro TsuboiDepartment of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan.
Koichi GotoDepartment of Thoracic Oncology, National Cancer Center Hospital East, Japan.
Zhihua YinDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Akiteru GotoDepartment of Cellular and Organ Pathology.
Yoshihiro MinamiyaDepartment of Thoracic Surgery, Graduate School of Medicine, Akita University, Akita City, Japan.
Kimihiro ShimizuDepartment of Integrative Center of General Surgery, Gunma University Hospital, Gunma, Japan.
Kazumi TanakaDepartment of Integrative Center of General Surgery, Gunma University Hospital, Gunma, Japan.
Tangchun WuDepartment of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Fusheng WeiChina National Environmental Monitoring Center, Beijing, People's Republic of China.
Jason Y Y WongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Jian SuGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.
Yeul Hong KimDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
In-Jae OhLung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasun-eup, Republic of Korea.
Fengju SongDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Victor Ho Fun LeeDepartment of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
Wu-Chou SuDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yuh-Min ChenDepartment of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Gee-Chen ChangSchool of Medicine, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.
Kuan-Yu ChenDivision of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
Ming-Shyan HuangDepartment of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Pan-Chyr YangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Hsien-Chih LinInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Yong-Bing XiangDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, People's Republic of China.
Adeline SeowSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Jae Yong ParkLung Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Sun-Seog KweonDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Chien-Jen ChenGenomic Research Center, Academia Sinica, Taipei, Taiwan.
Haixin LiDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, People's Republic of China.
Chen WuDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Biyun QianDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Daru LuMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Jianjun LiuSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Hyo-Sung JeonCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Chin-Fu HsiaoInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Jae Sook SungDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Ying-Huang TsaiDivision of Pulmonary and Critical Care Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Yoo Jin JungDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Huan GuoDepartment of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Zhibin HuDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Wen-Chang WangThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Charles C ChungDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Charles LawrenceWestat, Rockville, MD, USA.
Laurie BurdettDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Kevin B JacobsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Xingzhou HeChinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
Wei WuDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Junwen WangDepartment of Health Sciences Research.
Yuqing LiCancer Prevention Institute of California, Fremont, CA, USA.
Jin Eun ChoiCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Kyong Hwa ParkDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Sook Whan SungDepartment of Thoracic and Cardiovascular Surgery, Seoul St Mary's Hospital, The Catholic University of Korea, Republic of Korea.
Li LiuDepartment of Oncology, Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Chang Hyun KangDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Lingmin HuMinistry of Education Key Laboratory of Modern Toxicology.
Chung-Hsing ChenNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Tsung-Ying YangDivision of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Jun XuSchool of Public Health, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
Peng GuanDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Wen TanDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Chih-Liang WangDepartment of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Alan Dart Loon SihoeDepartment of Surgery, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
Ying ChenSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Yi Young ChoiCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Jen-Yu HungDepartment of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jun Suk KimDivision of Medical Oncology, Department of Internal Medicine, College of Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
Ho-Il YoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Chien-Chung LinDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
In Kyu ParkDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Ping XuDepartment of Oncology, Wuhan Iron and Steel (Group) Corporation Staff-Worker Hospital, Wuhan, People's Republic of China.
Jing DongMinistry of Education Key Laboratory of Modern Toxicology.
Christopher KimDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Qincheng HeDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Reury-Perng PerngChest Department, Taipei Veterans General Hospital, Taipei, Taiwan.
Chih-Yi ChenInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Roel VermeulenDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.
Junjie WuMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Wei-Yen LimAgency for Integrated Care, Singapore.
Kun-Chieh ChenDivision of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
John K C ChanDepartment of Pathology, Queen Elizabeth Hospital, Hong Kong, People's Republic of China.
Minjie ChuMinistry of Education Key Laboratory of Modern Toxicology.
Yao-Jen LiGenomic Research Center, Academia Sinica, Taipei, Taiwan.
Jihua LiQujing Center for Diseases Control and Prevention, Qujing, People's Republic of China.
Hongyan ChenMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Chong-Jen YuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Li JinMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Yen-Li LoInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Ying-Hsiang ChenInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jie LiuDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Taiki YamajiEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Yang YangShanghai Pulmonary Hospital, Shanghai, People's Republic of China.
Belynda HicksDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Kathleen WyattDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Shengchao A LiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Juncheng DaiDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Hongxia MaDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Guangfu JinDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Bao SongDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Zhehai WangDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Sensen ChengDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Xuelian LiDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Yangwu RenDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Ping CuiDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Motoki IwasakiEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Taichi ShimazuEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Shoichiro TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Junjie ZhuShanghai Pulmonary Hospital, Shanghai, People's Republic of China.
Gening JiangShanghai Pulmonary Hospital, Shanghai, People's Republic of China.
Ke FeiShanghai Pulmonary Hospital, Shanghai, People's Republic of China.
Guoping WuChina National Environmental Monitoring Center, Beijing, People's Republic of China.
Li-Hsin ChienInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Hui-Ling ChenInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Yu-Chun SuInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Fang-Yu TsaiNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Yi-Song ChenInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Jinming YuDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, People's Republic of China.
Victoria L StevensLaboratory Services, American Cancer Society, Atlanta, GA, USA.
Ite A Laird-OffringaDepartment of Surgery, Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Crystal N MarconettDepartment of Surgery, Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Dongxin LinDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Kexin ChenDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Yi-Long WuGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Hongbing ShenDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Takashi KohnoDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
National Cancer Institute · USNational Health Research Institutes · TWDivision of Cancer Epidemiology and GeneticsNanjing Medical University · CNTianjin Medical University Cancer Institute and Hospital · CNChina Medical University · CNChonnam National University · KRRIKEN Center for Integrative Medical Sciences · JPChinese Academy of Medical Sciences & Peking Union Medical College · CNKyungpook National University Medical Center · KRSeoul National University · KRShandong First Medical University · CNShanghai Pulmonary Hospital · CNUniversity of Hong Kong · HKAichi Cancer Center · JPFudan University · CNGuangdong Academy of Medical Sciences · CNKorea University · KRLeidos (United States) · USNational Taiwan University Hospital · TW
Funding
Molecular Epidemiology Studies of Occupational and Environmental ExposuresZIACP010121 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ROTHMAN, NATHANIEL · 2009 to 2025
$23.5MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MCancer Risk Reduction and Diet: A Cohort Study of WomenR37CA070867 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2009 to 2013
$4.7MNCI NIH HHS R37 CA070867NCI NIH HHS U19 CA148127NCI NIH HHS UM1 CA182910
Abstract
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.
Indexed as
AdenocarcinomaAdenocarcinoma of LungAntigens, NuclearAsian PeopleBromodomain Containing ProteinsButyrophilinsCase-Control StudiesErbB ReceptorsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeGerm-Line MutationHLA-DP beta-ChainsHumansLung NeoplasmsAntigens, NuclearBromodomain Containing ProteinsBTNL2 protein, humanButyrophilinsDCBLD2 protein, humanEGFR protein, humanErbB Receptorsfetal Alzheimer antigenHLA-DPB1 antigenHLA-DP beta-ChainsMembrane ProteinsNerve Tissue ProteinsTranscription Factors
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.