ArticleEuropean heart journal. Cardiovascular Imaging2017
Quantitative plaque features from coronary computed tomography angiography to identify regional ischemia by myocardial perfusion imaging.
Article in European heart journal. Cardiovascular Imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Sex-Specific Computed Tomography Coronary Plaque Characterization and Risk of Myocardial Infarction.JACC. Cardiovascular imaging · 2021Trial
- Design and rationale of the WARRIOR ancillary study for coronary CT angiographic analysis.American heart journal · 2026Article
- Quantitative Coronary CT Angiography and Pericoronary Adipose Tissue in Acute Myocardial Infarction: Relationship with Dynamic Myocardial Perfusion SPECT.Diagnostics (Basel, Switzerland) · 2025Article
- Coronary Computed Tomography Angiography Atherosclerotic Plaque Volume as A Predictor of Myocardial Blood Flow Impairment in Non-Obstructive Coronary Artery Disease.Reviews in cardiovascular medicine · 2025Article
- Patient-Specific Myocardial Infarction Risk Thresholds From AI-Enabled Coronary Plaque Analysis.Circulation. Cardiovascular imaging · 2024Article
- Application of Quantitative Assessment of Coronary Atherosclerosis by Coronary Computed Tomographic Angiography.Korean journal of radiology · 2024Review
- Association between myocardial ischemia and plaque characteristics in chronic total occlusion.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Atherosclerotic plaque characteristics on quantitative coronary computed tomography angiography associated with ischemia on positron emission tomography in diabetic patients.The international journal of cardiovascular imaging · 2022Article
- Association between coronary plaque volume and myocardial ischemia detected by dynamic perfusion CT imaging.Frontiers in cardiovascular medicine · 2022Article
- Relationship of age, atherosclerosis and angiographic stenosis using artificial intelligence.Open heart · 2021Article
- Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery disease.International journal of cardiology. Heart & vasculature · 2021Article
- Noncalcified plaque burden quantified from coronary computed tomography angiography improves prediction of side branch occlusion after main vessel stenting in bifurcation lesions: results from the CT-PRECISION registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- Physiology and coronary artery disease: emerging insights from computed tomography imaging based computational modeling.The international journal of cardiovascular imaging · 2020Review
- [Evaluation of Myocardial Ischemia Using Coronary Computed Tomography Angiography in Patients with Stable Angina].Taehan Yongsang Uihakhoe chi · 2020Review
- Quantification of plaque characteristics detected by dual source computed tomography angiography to predict myocardial ischemia as assessed by single photon emission computed tomography myocardial perfusion imaging.Quantitative imaging in medicine and surgery · 2019Article
- Deep learning-based stenosis quantification from coronary CT Angiography.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Quantitative global plaque characteristics from coronary computed tomography angiography for the prediction of future cardiac mortality during long-term follow-up.European heart journal. Cardiovascular Imaging · 2017Article
- Coronary atherosclerosis imaging by CT to improve clinical outcomes.Journal of cardiovascular computed tomographyReview
Corrections and comments
- Commented on by
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
aimsWe aimed to investigate whether quantitative plaque features measured from coronary CT angiography (CCTA) predict ischemia by myocardial perfusion SPECT imaging (MPI). METHODS AND
resultsHundred and eighty-four consecutive patients (63% males) with suspected-coronary artery disease, undergoing hybrid CCTA, and attenuation corrected solid state 99mTc stress/rest MPI and single vessel ischemia were considered. Quantitative analysis of CCTA derived non-calcified plaque (NCP), low-density NCP [< 30 Hounsfield Units (HU)] (LDNCP), calcified and total plaque burdens (%, normalized to vessel volume), maximum diameter stenosis and contrast density difference (CD, maximum difference in HU/lumen area within lesion). Normal thresholds for plaque features were defined as 95th percentile thresholds, from 40% of vessels with non-ischemic MPI regions. These vessels were excluded from further analysis. Regional ischemia (≥ 2%) was quantified from MPI. All plaque features were higher in arteries corresponding to ischemia (P < 0.003 for all). In multi-variable analysis, abnormal NCP burden [odds ratio (OR) 2.6], LDNCP burden (OR 3.9), and CD (OR 2.7) were significantly associated with ischemia, whereas stenosis ≥ 50% was not (P = 0.14). In a subset of vessels with ≥ 50% stenosis, LDNCP burden (OR 4.3, P = 0.008) and CD (OR 3.7, P = 0.029) were associated with ischemia. In subsets of vessels with stenosis 30-69% and ≥ 70%, abnormal LDNCP burden (OR 6.4, P = 0.006) and CD (OR 7.3, P = 0.02) were associated with ischemia.
conclusionsQuantitative plaque features obtained from CCTA, LDNCP, and CD, are associated with ischemia by MPI independent of stenosis. LDNCP burden and CD are associated with ischemia in stenosis 30-69% and ≥ 70%, respectively.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.