Evidence map›Paper›PMID 28025213›Full record

ReviewEuropean heart journal. Cardiovascular pharmacotherapy2017

Non-vitamin-K oral anticoagulants and laboratory testing: now and in the future: Views from a workshop at the European Medicines Agency (EMA).

Tomas Salmonson, Jean-Michel Dogné, Heidi Janssen, Juan Garcia Burgos, Paul Blake

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in European heart journal. Cardiovascular pharmacotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04271293 (anticOagulanti oRali in pazIenti fraGili Con gAstrostoMia endoscopIca Percutanea e fIbrillazione Atriale), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04271293 completednot on this mapstarted 2020, after this paper: background citation

anticOagulanti oRali in pazIenti fraGili Con gAstrostoMia endoscopIca Percutanea e fIbrillazione Atriale

TypeobservationalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2020 to 2021Enrolled12ConditionsAtrial FibrillationArmsEdoxaban
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. The Influence of High Body Mass Index (BMI > 35 kg/mAmerican journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Observational
  7. 2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021
    Article
  8. Review
  9. Point-of-Care Diagnostics in Coagulation Management.Sensors (Basel, Switzerland) · 2020
    Review
  10. Review
  11. Who approves/pays for additional monitoring?European heart journal supplements : journal of the European Society of Cardiology · 2019
    Article
  12. Monitoring of biomarkers in heart failure.European heart journal supplements : journal of the European Society of Cardiology · 2019
    Article
  13. NOACs in Anesthesiology.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2019
    Review
  14. Patients on NOACs in the Emergency Room.Current neurology and neuroscience reports · 2019
    Review
  15. Review
  16. Article
  17. Review
  18. Direct Oral Anticoagulants for Portal Vein Thrombosis in Cirrhosis: From Pharmacology to Clinical Practice.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tomas SalmonsonCommittee Chair, Committee for Medicinal Products for Human Use, EMA, London E14 5EU, UK.
Jean-Michel DognéCommittee Member, Pharmacovigilance Risk Assessment Committee, EMA, London E14 5EU, UK.
Heidi JanssenHead of Office, Endocrinology, Metabolism & Cardiovascular Office, EMA, London E14 5EU, UK.
Juan Garcia BurgosHead of Service, Medical and Health Information Service, EMA, London E14 5EU, UK.
Paul BlakeScientific Officer, Medical and Health Information Service, EMA, London E14 5EU, UK paul.blake@ema.europa.eu.
European Medicines Agency · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In contrast to vitamin K antagonists, no routine coagulation monitoring is required in patients taking non-vitamin-K oral anticoagulants (NOACs). However, dosing must take into account factors such as patient age, renal function, and accompanying haemorrhagic risk. There has been considerable debate about when laboratory measurement might be appropriate and which tests should be used. A workshop at the European Medicines Agency recently discussed the evidence about laboratory measurement from formal studies, clinical experience, and the multiple perspectives on NOAC treatment, and considered how our knowledge might be further enhanced.

Indexed as

Education, MedicalSocieties, MedicalAdministration, OralAnticoagulantsBlood CoagulationCardiologyEuropeHumansStrokeAnticoagulantsAnticoagulationCoagulation testsDirect Oral AnticoagulantsDOACsNOACsNon-vitamin-K oral anticoagulants

Identifiers

PMID28025213
PMCPMC5216197
OpenAlexW2566834448

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.