Evidence map›Paper›PMID 28025166›Full record

ReviewCurrent opinion in chemical biology2017

Considerations when choosing a genetic model organism for metabolomics studies.

Laura K Reed, Charles F Baer, Arthur S Edison

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Transforming beef quality through healthy breeding: a strategy to reduce carcinogenic compounds and enhance human health: a review.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Metabolomic analysis of tomato seed germination.Metabolomics : Official journal of the Metabolomic Society · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Laura K ReedDepartment of Biological Sciences, University of Alabama, 300 Hackberry Lane, Tuscaloosa, AL 35487, USA.
Charles F BaerDepartment of Biology, University of Florida Genetics Institute, University of Florida, 621 Bartram Hall, 876 Newell Dr., Gainesville, FL 32611-8525, USA.
Arthur S EdisonDepartments of Genetics and Biochemistry, Institute of Bioinformatics and Complex Carbohydrate Center, University of Georgia, 315 Riverbend Rd, Athens, GA 30602, USA. Electronic address: aedison@uga.edu.
University of Alabama · USUniversity of Florida · USUniversity of Georgia · US

Funding

Southeast Resource Center for Integrated Metabolomics (SECIM)U24DK097209 · NIDDK · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S, YOST, RICHARD A. · 2013 to 2017
$9.2M
Genetic Basis of Genotype-by-Environment Interactions Underlying Physiological MoR01GM098856 · NIGMS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI MOTSINGER-REIF, ALISON, REED, LAURA K · 2011 to 2015
$1.3M
Determination of the distribution of fitness effects of mutations in C. elegansR01GM107227 · NIGMS · UNIVERSITY OF FLORIDA · PI BAER, CHARLES F · 2014 to 2017
$1.1M
NIDDK NIH HHS U24 DK097209NIGMS NIH HHS R01 GM098856NIGMS NIH HHS R01 GM107227
6 · The paper itself

Abstract

Model organisms are important in many areas of chemical biology. In metabolomics, model organisms can provide excellent samples for methods development as well as the foundation of comparative phylometabolomics, which will become possible as metabolomics applications expand. Comparative studies of conserved and unique metabolic pathways will help in the annotation of metabolites as well as provide important new targets of investigation in biology and biomedicine. However, most chemical biologists are not familiar with genetics, which needs to be considered when choosing a model organism. In this review we summarize the strengths and weaknesses of several genetic systems, including natural isolates, recombinant inbred lines, and genetic mutations. We also discuss methods to detect targets of selection on the metabolome.

Indexed as

Genetic Association StudiesModels, AnimalAnimalsGene ExpressionGenotypeHumansMetabolic Networks and PathwaysMetabolomicsMutationYeasts

Identifiers

PMID28025166
PMCPMC5337163
OpenAlexW2561920654

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.