Evidence map›Paper›PMID 28025046›Full record

ReviewJournal of molecular and cellular cardiology2017

CaMKII is a nodal signal for multiple programmed cell death pathways in heart.

Ning Feng, Mark E Anderson

Open access · greenAbstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 107 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Mitochondria-associated programmed cell death in pancreatic β cell of T2DM.Apoptosis : an international journal on programmed cell death · 2026
    Review
  6. Stress-Induced calcium mishandling in cardiac (Patho)physiology.Cellular and molecular life sciences : CMLS · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. CYR61 as a Potential Apoptosis Biomarker in Osteoarthritis with Comorbidities.Journal of musculoskeletal & neuronal interactions · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. International journal of molecular medicine · 2024
    Article
  19. Review
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ning FengDepartment of Medicine/Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: nfeng3@jhmi.edu.
Mark E AndersonDepartment of Medicine/Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Physiology and the Program in Cellular and Molecular Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: mark.anderson@jhmi.edu.
Johns Hopkins University · US

Funding

Mitochondrial Calmodulin Kinase II in Physiology and DiseaseR01HL070250 · NHLBI · VANDERBILT UNIVERSITY · PI ANDERSON, MARK E · 2002 to 2017
$5.2M
Thoracic Veins and Sustained Atrial FibrillationR01HL071140 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CHEN, PENG-SHENG · 2002 to 2014
$4.7M
Methionine sulfoxide reductase A and oxidized CaMKII in structural heart diseaseR01HL079031 · NHLBI · UNIVERSITY OF IOWA · PI ANDERSON, MARK E · 2006 to 2015
$3.3M
CaMKII in Sinus Node Physiology and DiseaseR01HL096652 · NHLBI · UNIVERSITY OF IOWA · PI ANDERSON, MARK E · 2009 to 2016
$3.0M
Oxidized CaMKII in Atrial FibrillationR01HL113001 · NHLBI · UNIVERSITY OF IOWA · PI ANDERSON, MARK E · 2012 to 2016
$1.9M
The Role of Myocardial BDNF signaling in Myocardial physiology and myocardial response to pathological stressK08HL130604 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FENG, NING · 2016 to 2021
$690k
NHLBI NIH HHS K08 HL130604NHLBI NIH HHS R01 HL070250NHLBI NIH HHS R01 HL071140NHLBI NIH HHS R01 HL079031NHLBI NIH HHS R01 HL096652NHLBI NIH HHS R01 HL113001
6 · The paper itself

Abstract

Sustained Ca

Indexed as

ApoptosisSignal TransductionAnimalsBiomarkersCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Endoplasmic Reticulum StressHumansIntracellular SpaceMitochondria, HeartMyocardiumMyocytes, CardiacNecrosisOxidation-ReductionBiomarkersCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2ApoptosisCaMKIIMitochondriaMitochondrial permeability transition poreNecroptosisOxidized CaMKIIProgrammed cell deathRIP3ROS

Identifiers

PMID28025046
PMCPMC5404235
OpenAlexW2565584878

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.