Evidence map›Paper›PMID 28024904›Full record

ArticleAnnals of epidemiology2017

Early-life mortality risks in opposite-sex and same-sex twins: a Danish cohort study of the twin testosterone transfer hypothesis.

Linda Juel Ahrenfeldt, Lisbeth Aagaard Larsen, Rune Lindahl-Jacobsen, Axel Skytthe, Jacob V B Hjelmborg, Sören Möller, Kaare Christensen

Abstract readComparative Study
In one paragraph

Article in Annals of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Cortisol advantage of neighbouring the opposite sexRoyal Society open science · 2018
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linda Juel AhrenfeldtDepartment of Public Health, The Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark; Department of Public Health, Max-Planck Odense Center on the Biodemography of Aging, University of Southern Denmark, Odense C, Denmark. Electronic address: lahrenfeldt@health.sdu.dk.
Lisbeth Aagaard LarsenDepartment of Public Health, The Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark.
Rune Lindahl-JacobsenDepartment of Public Health, The Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark; Department of Public Health, Max-Planck Odense Center on the Biodemography of Aging, University of Southern Denmark, Odense C, Denmark.
Axel SkyttheDepartment of Public Health, The Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark.
Jacob V B HjelmborgDepartment of Public Health, The Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark.
Sören MöllerDepartment of Public Health, The Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark.
Kaare ChristensenDepartment of Public Health, The Danish Twin Registry, Unit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense C, Denmark; Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark.

Funding

TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROACH, DEBORAH A · 1990 to 2008
$17.5M
THE RANGE OF MALE-FEMALE MORTALITY DIFFERENCESP01AG031719 · NIA · DUKE UNIVERSITY · PI ZENG, YI · 2009 to 2020
$10.2M
NIA NIH HHS P01 AG008761NIA NIH HHS P01 AG031719
6 · The paper itself

Abstract

purposeTo investigate the twin testosterone transfer (TTT) hypothesis by comparing early-life mortality risks of opposite-sex (OS) and same-sex (SS) twins during the first 15 years of life.

methodsWe performed a population-based cohort study to compare mortality in OS and SS twins. We included 68,629 live-born Danish twins from 1973 to 2009 identified through the Danish Twin Registry and performed piecewise stratified Cox regression and log-binomial regression.

resultsAmong 1933 deaths, we found significantly higher mortality for twin boys than for twin girls. For both sexes, OS twins had lower mortality than SS twins; the difference persisted for the first year of life for boys and for the first week of life for girls.

conclusionsAlthough the mortality risk for OS boys was in the expected direction according to the TTT hypothesis, the results for OS girls pointed in the opposite direction, providing no clear evidence for the TTT hypothesis.

Indexed as

Cause of DeathAdolescentChildChild, PreschoolCohort StudiesDenmarkFemaleHumansInfantInfant, NewbornMaleRegression AnalysisRisk AssessmentSex FactorsTestosteroneTwins, DizygoticTestosteroneMortalityOpposite-sexSame-sexSexTwins

Identifiers

PMID28024904
PMCPMC5439218

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.