Evidence map›Paper›PMID 28024351›Full record

ArticleACS nano2016

Understanding the Kinetics of Protein-Nanoparticle Corona Formation.

Oriol Vilanova, Judith J Mittag, Philip M Kelly, Silvia Milani, Kenneth A Dawson, Joachim O Rädler, Giancarlo Franzese

Abstract read
In one paragraph

Article in ACS nano, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Oriol VilanovaSecció de Física Estadística i Interdisciplinària-Departament de Física de la Matèria Condensada, Facultat de Física, Universitat de Barcelona , Martí i Franquès 1, Barcelona 08028, Spain.ORCID 0000-0003-1242-2377
Judith J MittagFaculty of Physics, Center for Nanoscience, Ludwig-Maximilians-Universität , Geschwister-Scholl-Platz 1, Munich 80539, Germany.
Philip M Kelly
Silvia MilaniFaculty of Physics, Center for Nanoscience, Ludwig-Maximilians-Universität , Geschwister-Scholl-Platz 1, Munich 80539, Germany.
Kenneth A Dawson
Joachim O RädlerFaculty of Physics, Center for Nanoscience, Ludwig-Maximilians-Universität , Geschwister-Scholl-Platz 1, Munich 80539, Germany.
Giancarlo FranzeseSecció de Física Estadística i Interdisciplinària-Departament de Física de la Matèria Condensada, Facultat de Física, Universitat de Barcelona , Martí i Franquès 1, Barcelona 08028, Spain.ORCID 0000-0003-3006-2766

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When a pristine nanoparticle (NP) encounters a biological fluid, biomolecules spontaneously form adsorption layers around the NP, called "protein corona". The corona composition depends on the time-dependent environmental conditions and determines the NP's fate within living organisms. Understanding how the corona evolves is fundamental in nanotoxicology as well as medical applications. However, the process of corona formation is challenging due to the large number of molecules involved and to the large span of relevant time scales ranging from 100 μs, hard to probe in experiments, to hours, out of reach of all-atoms simulations. Here we combine experiments, simulations, and theory to study (i) the corona kinetics (over 10

Indexed as

NanoparticlesProtein BindingProtein CoronaHumansKineticsSilicon DioxideProtein CoronaSilicon Dioxidecompetitive protein adsorptionDCSFCSmicroscale thermophoresismolecular simulationprotein coronaprotein−nanoparticle interactionsSDS-PAGE

Identifiers

PMID28024351
PMCPMC5391497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.