ReviewCurrent opinion in neurobiology2017
In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory.
Review in Current opinion in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Aspects of plant intelligence (ii).Plant signaling & behavior · 2026Review
- Article
- Plant intelligence dux: a comprehensive rebuttal of Kingsland and Taiz.Protoplasma · 2025Article
- SWI/SNF Complex Connects Signaling and Epigenetic State in Cells of Nervous System.Molecular neurobiology · 2025Review
- Epigenetic mechanisms impacted by chronic stress across the rodent lifespan.Neurobiology of stress · 2022Article
- Review
- Multi-Domain Touchscreen-Based Cognitive Assessment of C57BL/6J Female Mice Shows Whole-Body Exposure toFrontiers in behavioral neuroscience · 2021Article
- Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation.PloS one · 2021Article
- Loop Interrupted: Dysfunctional Chromatin Relations in Neurological Diseases.Frontiers in genetics · 2021Review
- MeCP2 Levels Regulate the 3D Structure of Heterochromatic Foci in Mouse Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Spatial genome exploration in the context of cognitive and neurological disease.Current opinion in neurobiology · 2019Review
- Three-dimensional chromosome architecture and drug addiction.Current opinion in neurobiology · 2019Review
- Hippocampal stimulation promotes intracellular Tip60 dynamics with concomitant genome reorganization and synaptic gene activation.Molecular and cellular neurosciences · 2019Article
- MeCP2: A Critical Regulator of Chromatin in Neurodevelopment and Adult Brain Function.International journal of molecular sciences · 2019Review
- Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing.Genome research · 2019Article
- Sex Differences in the Epigenome: A Cause or Consequence of Sexual Differentiation of the Brain?Genes · 2019Review
- Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair.Neurobiology of learning and memory · 2019Review
- How the epigenome integrates information and reshapes the synapse.Nature reviews. Neuroscience · 2019Review
- Chromatin Regulation in Complex Brain Disorders.Current opinion in behavioral sciences · 2019Article
- Cyto-nuclear shuttling of afadin is required for rapid estradiol-mediated modifications of histone H3.Neuropharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Different aspects of learning, memory, and cognition are regulated by epigenetic mechanisms such as covalent DNA modifications and histone post-translational modifications. More recently, the modulation of chromatin architecture and nuclear organization is emerging as a key factor in dynamic transcriptional regulation of the post-mitotic neuron. For instance, neuronal activity induces relocalization of gene loci to 'transcription factories', and specific enhancer-promoter looping contacts allow for precise transcriptional regulation. Moreover, neuronal activity-dependent DNA double-strand break formation in the promoter of immediate early genes appears to overcome topological constraints on transcription. Together, these findings point to a critical role for genome topology in integrating dynamic environmental signals to define precise spatiotemporal gene expression programs supporting cognitive processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.