Evidence map›Paper›PMID 28024156›Full record

ArticleNature materials2017

Designer vaccine nanodiscs for personalized cancer immunotherapy.

Rui Kuai, Lukasz J Ochyl, Keith S Bahjat, Anna Schwendeman, James J Moon

Abstract read
In one paragraph

Article in Nature materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 468 papers.

0numbers the graph read from it
0cells of the map it votes in
468citing papers in PubMed
37.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

468 citing papers in PubMed, 1,034 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. EngineeredMolecular therapy. Oncology · 2026
    Article
  11. Article
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  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

408 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Rui KuaiDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA.
Lukasz J OchylDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA.
Keith S BahjatDiscovery Research, Bristol-Myers Squibb Biologics Discovery California, Redwood City, California 94063, USA.
Anna SchwendemanDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA.
James J MoonDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA.
BioSurfaces (United States) · USUniversity of Michigan–Ann Arbor · USBristol-Myers Squibb (United States) · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Synthetic HDL_a potential sepsis therapyR01GM113832 · NIGMS · UNIVERSITY OF KENTUCKY · PI LI, XIANG-AN, SCHWENDEMAN, ANNA · 2015 to 2019
$3.0M
Elicitation of mucosal immune responses against HIVR01AI127070 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOON, JAMES J. · 2016 to 2020
$2.3M
Nanomaterials for eliciting anti-tumor T-cells-Diversity SupplementR01CA210273 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOON, JAMES J. · 2017 to 2021
$2.2M
Tuning Biomaterials-immune cell interactions for treatment of glioblastoma multiformeR01EB022563 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOON, JAMES J. · 2016 to 2019
$1.7M
HDL-Loaded Nanoparticles for Glioma TherapeuticsR21NS091555 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2015 to 2016
$427k
Elicitation of mucosal immune responses against HIVR56AI127070 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOON, JAMES J. · 2016 to 2016
$293k
Delivery of Particle Vaccines to Control Trafficking Patterns of T CellsK22AI097291 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOON, JAMES J. · 2013 to 2014
$270k
NCATS NIH HHS UL1 TR000433NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA210273NIAID NIH HHS HHSN272201300006CNIAID NIH HHS K22 AI097291NIAID NIH HHS R01 AI127070NIAID NIH HHS R56 AI127070NIBIB NIH HHS R01 EB022563NIGMS NIH HHS R01 GM113832NINDS NIH HHS R21 NS091555
6 · The paper itself

Abstract

Despite the tremendous potential of peptide-based cancer vaccines, their efficacy has been limited in humans. Recent innovations in tumour exome sequencing have signalled the new era of personalized immunotherapy with patient-specific neoantigens, but a general methodology for stimulating strong CD8α

Indexed as

Antigens, NeoplasmCancer VaccinesEpitopesNanostructuresNeoplasms, ExperimentalVaccinationAnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleHumansImmunity, CellularMiceAntigens, NeoplasmCancer VaccinesEpitopes

Identifiers

PMID28024156
PMCPMC5374005
OpenAlexW2564809671

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.