ArticleJCI insight2016
HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P
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Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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0cells of the map it votes in
38citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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Who cites it
38 citing papers in PubMed, 69 citations in OpenAlex.
- Sphingolipid homeostasis and dysregulation in liver function and disease.Life metabolism · 2026Review
- Beyond High-density Lipoprotein-cholesterol: Unraveling the Complexity of High-density Lipoprotein Functionality.Journal of atherosclerosis and thrombosis · 2025Review
- Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics.Signal transduction and targeted therapy · 2025Review
- SPHK1/S1PR1/PPAR-α axis restores TJs between uroepithelium providing new ideas for IC/BPS treatment.Life science alliance · 2025Article
- Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature.Cardiovascular research · 2024Article
- Regulation of cellular and systemic sphingolipid homeostasis.Nature reviews. Molecular cell biology · 2024Review
- Anatomical and immunohistochemical analyses of the fusion of the premaxillary-maxillary suture in human fetuses.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2024Article
- Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation.Science signaling · 2024Article
- Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes.Nature communications · 2024Article
- Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases.European journal of clinical pharmacology · 2024Review
- Kidney derived apolipoprotein M and its role in acute kidney injury.Frontiers in pharmacology · 2024Article
- The Sphingosine 1-Phosphate Axis: an Emerging Therapeutic Opportunity for Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung.Acta pharmaceutica Sinica. B · 2023Article
- Unveiling the power of microenvironment in liver regeneration: an in-depth overview.Frontiers in genetics · 2023Review
- Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages.Antioxidants (Basel, Switzerland) · 2022Article
- Molecular Advances in MAFLD-A Link between Sphingolipids and Extracellular Matrix in Development and Progression to Fibrosis.International journal of molecular sciences · 2022Review
- Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH.Molecular metabolism · 2022Article
- Thorny ground, rocky soil: Tissue-specific mechanisms of tumor dormancy and relapse.Seminars in cancer biology · 2022Review
- Angiodiversity and organotypic functions of sinusoidal endothelial cells.Angiogenesis · 2021Review
- Ceramides and sphingosine-1-phosphate mediate the distinct effects of M1/M2-macrophage infusion on liver recovery after hepatectomy.Cell death & disease · 2021Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 3 countries.
Bi-Sen DingKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Catherine H LiuCenter for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, New York, USA.
Yue SunKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Yutian ChenKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Steven L SwendemanCenter for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, New York, USA.
Bongnam JungDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Deebly ChavezAnsary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Zhongwei CaoKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Christina ChristoffersenDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Lars Bo NielsenDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
Susan R SchwabDepartment of Pathology, Skirball Institute, New York University School of Medicine, New York, New York, USA.
Shahin RafiiAnsary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Timothy HlaCenter for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, New York, USA.
Institute of Biomedical Science · GBRigshospitalet · DKUppsala University · SE
Funding
The role of SPNS2 in T cell responsesR01AI085166 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Susan Ruth Schwab · 2011 to 2026
$6.5MSphingolipid modulators of vascular growth & homeostasisR37HL067330 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI HLA, TIMOTHY TUN · 2006 to 2015
$3.9MSphingosine 1-phosphate receptors in vascular homeostasis and pathologyR01HL089934 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI HLA, TIMOTHY TUN · 2008 to 2016
$3.3MEndothelial cell-derived MMP14 in lung alveolar regeneration and fibrosisR01HL130826 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI POWELL, CHARLES A. · 2016 to 2020
$2.4MIdentification of vascular-derived signals for alveolar lung repairR01HL119872 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAFII, SHAHIN · 2013 to 2016
$2.3MContribution of the vascular niche to the hematopoietic reconstitution.R01HL097797 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAFII, SHAHIN · 2009 to 2012
$1.7MNHLBI NIH HHS R01 HL089934NHLBI NIH HHS R01 HL097797NHLBI NIH HHS R01 HL119872NHLBI NIH HHS R01 HL130826NHLBI NIH HHS R37 HL067330NIAID NIH HHS R01 AI085166
Abstract
Regeneration of hepatic sinusoidal vasculature is essential for non-fibrotic liver regrowth and restoration of its metabolic capacity. However, little is known about how this specialized vascular niche is regenerated. Here we show that activation of endothelial sphingosine-1-phosphate receptor-1 (S1P
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.