Evidence map›Paper›PMID 28018911›Full record

ArticleJournal of fungi (Basel, Switzerland)2016

A Quantitative Model to Estimate Drug Resistance in Pathogens.

Frazier N Baker, Melanie T Cushion, Aleksey Porollo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Analysis of Mutations inInfection and drug resistance · 2024
    Article
  2. Update on Dihydropteroate Synthase (DHPS) Mutations inJournal of fungi (Basel, Switzerland) · 2021
    Review
  3. Special Issue: Novel Antifungal Drug Discovery.Journal of fungi (Basel, Switzerland) · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Frazier N BakerDepartment of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, OH, USA 45221; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA 45229.
Melanie T CushionDepartment of Internal Medicine University of Cincinnati College of Medicine, Cincinnati, OH, USA 45267; melanie; The Veterans Affairs Medical Center, Cincinnati, OH, USA 45220.
Aleksey PorolloCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA 45229; Department of Biomedical Informatics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA 45267.
Cincinnati Children's Hospital Medical Center · USVeterans Health Administration · US

Funding

Directed Culturing of Pneumocystis Using MetatranscriptomicsR01HL119190 · NHLBI · UNIVERSITY OF CINCINNATI · PI CUSHION, MELANIE T, POROLLO, ALEXEY · 2013 to 2017
$2.1M
NHLBI NIH HHS R01 HL119190
6 · The paper itself

Abstract

Pneumocystis pneumonia (PCP) is an opportunistic infection that occurs in humans and other mammals with debilitated immune systems. These infections are caused by fungi in the genus Pneumocystis, which are not susceptible to standard antifungal agents. Despite decades of research and drug development, the primary treatment and prophylaxis for PCP remains a combination of trimethoprim (TMP) and sulfamethoxazole (SMX) that targets two enzymes in folic acid biosynthesis, dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS), respectively. There is growing evidence of emerging resistance by

Indexed as

amino acid coevolutionamino acid covariancedrug resistancefolate biosynthesisPneumocystis jiroveciiPneumocystis pneumoniaQSAR

Identifiers

PMID28018911
PMCPMC5179226
OpenAlexW2560001440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.