ReviewFrontiers in oncology2016
Time and Circumstances: Cancer Cell Metabolism at Various Stages of Disease Progression.
Review in Frontiers in oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- In Vitro Cytotoxic Activity ofMolecules (Basel, Switzerland) · 2026Article
- NAC regulates metabolism and cell fate in intestinal stem cells.Science advances · 2025Article
- Comprehensive analysis of the clinical and biological significances of cholesterol metabolism in lower-grade gliomas.BMC cancer · 2023Article
- Long non-coding RNAs modulate tumor microenvironment to promote metastasis: novel avenue for therapeutic intervention.Frontiers in cell and developmental biology · 2023Review
- Leptomeningeal metastatic cells adopt two phenotypic states.Cancer reports (Hoboken, N.J.) · 2022Article
- Mitochondria dysfunction in circulating tumor cells.Frontiers in oncology · 2022Review
- Cancer cell metabolic plasticity in migration and metastasis.Clinical & experimental metastasis · 2021Review
- Transitional cell carcinoma matrix stiffness regulates the osteopontin and YAP expression in recurrent patients.Molecular biology reports · 2021Article
- Article
- NNT-induced tumor cell "slimming" reverses the pro-carcinogenesis effect of HIF2a in tumors.Clinical and translational medicine · 2021Article
- Mechanisms for Modulating Anoikis Resistance in Cancer and the Relevance of Metabolic Reprogramming.Frontiers in oncology · 2021Review
- Targeting Mitochondrial Protein Expression as a Future Approach for Cancer Therapy.Frontiers in oncology · 2021Review
- Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment.Frontiers in oncology · 2021Review
- Article
- Identification of an ATP metabolism-related signature associated with prognosis and immune microenvironment in gliomas.Cancer science · 2020Article
- Non-Coding RNAs Operate in the Crosstalk Between Cancer Metabolic Reprogramming and Metastasis.Frontiers in oncology · 2020Review
- The Role of Metabolic Changes in Shaping the Fate of Cancer-Associated Adipose Stem Cells.Frontiers in cell and developmental biology · 2020Article
- Metabolic Plasticity and Epithelial-Mesenchymal Transition.Journal of clinical medicine · 2019Review
- Tumor Cell "Slimming" Regulates Tumor Progression through PLCL1/UCP1-Mediated Lipid Browning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Is the Response of Tumours Dependent on the Dietary Input of Some Amino Acids or Ratios among Essential and Non-Essential Amino Acids? All That Glitters Is Not Gold.International journal of molecular sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past decade, research into the unique ways, in which cancer cells skew their metabolism, has had a renaissance-for the repeated time over more than 80 years since the discovery of an inherent preference for glycolysis. Importantly, the Warburg effect that arises in primary neoplasms is not the sole prominent metabolic phenomenon. Once the transformed cells are shed from their initial growth and begin the process of metastasis, their energy requirements change and they adapt to the increased demand for adenosine triphosphate, which if not satisfied would lead to anoikis. At that stage, oxidoreductases and the respiratory chain are activated. Furthermore, the intrinsic metabolic characteristics of tumor cells may be influenced by extrinsic factors, comprising metabolite secretions from stromal cells or acidification and nutrient deprivation in the late-stage hypoxic environment. While there is metabolic adjustment in cancer cells throughout the disease history, its phenotypic manifestation changes at various times. This stage selectivity has implications for pharmacotherapy ambitions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.