Evidence map›Paper›PMID 28018854›Full record

ArticleNeuroImage. Clinical2017

Cholinergic depletion and basal forebrain volume in primary progressive aphasia.

Jolien Schaeverbeke, Charlotte Evenepoel, Rose Bruffaerts, Koen Van Laere, Guy Bormans, Eva Dries, Thomas Tousseyn, Natalie Nelissen, Ronald Peeters, Mathieu Vandenbulcke and 2 more

Open access · goldAbstract read
In one paragraph

Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Jolien SchaeverbekeLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Herestraat 49, Box 1027, Leuven 3000, Belgium; Alzheimer Research Centre, KU Leuven, Herestraat 49, Leuven 3000, Belgium; Leuven Institute of Neuroscience and Disease, Herestraat 49, Leuven 3000, Belgium.
Charlotte EvenepoelLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Herestraat 49, Box 1027, Leuven 3000, Belgium; Alzheimer Research Centre, KU Leuven, Herestraat 49, Leuven 3000, Belgium; Leuven Institute of Neuroscience and Disease, Herestraat 49, Leuven 3000, Belgium.
Rose BruffaertsLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Herestraat 49, Box 1027, Leuven 3000, Belgium; Neurology Department, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium.
Koen Van LaereLeuven Institute of Neuroscience and Disease, Herestraat 49, Leuven 3000, Belgium; Nuclear Medicine and Molecular Imaging, KU Leuven and University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium.
Guy BormansNuclear Medicine and Molecular Imaging, KU Leuven and University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium; Laboratory of Radiopharmaceutical Chemistry, KU Leuven, Herestraat 49, Leuven 3000, Belgium.
Eva DriesNeurology Department, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium.
Thomas TousseynPathology Department, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium.
Natalie NelissenLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Herestraat 49, Box 1027, Leuven 3000, Belgium; Experimental Psychology Department, Oxford University, 9 South Parks Road, Oxford OX1 3UD, United Kingdom.
Ronald PeetersRadiology Department, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium.
Mathieu VandenbulckeAlzheimer Research Centre, KU Leuven, Herestraat 49, Leuven 3000, Belgium; Old Age Psychiatry Department, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium.
Patrick DupontLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Herestraat 49, Box 1027, Leuven 3000, Belgium; Alzheimer Research Centre, KU Leuven, Herestraat 49, Leuven 3000, Belgium; Leuven Institute of Neuroscience and Disease, Herestraat 49, Leuven 3000, Belgium.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Herestraat 49, Box 1027, Leuven 3000, Belgium; Alzheimer Research Centre, KU Leuven, Herestraat 49, Leuven 3000, Belgium; Leuven Institute of Neuroscience and Disease, Herestraat 49, Leuven 3000, Belgium; Neurology Department, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium.
KU Leuven · BEUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary progressive aphasia (PPA) is a heterogeneous syndrome with various neuropathological causes for which no medical treatment with proven efficacy exists. Basal forebrain (BF) volume loss has been reported in PPA but its relation to cholinergic depletion is still unclear. The primary objective of this study was to investigate whether cholinergic alterations occur in PPA variants and how this relates to BF volume loss. An academic memory clinic based consecutive series of 11 PPA patients (five with the semantic variant (SV), four with the logopenic variant (LV) and two with the nonfluent variant (NFV)) participated in this cross-sectional

Indexed as

Aphasia, Primary ProgressiveAcetylcholinesteraseAdultAgedAtrophyBasal ForebrainCarbon RadioisotopesCerebral CortexCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyPropionatesAcetylcholinesteraseCarbon RadioisotopesN-methylpiperidin-4-yl propionatePropionatesAcetylcholinesteraseBasal forebrainKinetic modelingN-[11C]-Methylpiperidin-4-yl propionatePETPrimary progressive aphasia

Identifiers

PMID28018854
PMCPMC5176031
OpenAlexW2559159818

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.