Evidence map›Paper›PMID 28018719›Full record

ArticleBiomedical optics express2016

Supra-organization and optical anisotropies of the extracellular matrix in the amniotic membrane and limbal stroma before and after explant culture.

Gisele P Valdetaro, Marcela Aldrovani, Ivan R M Padua, Priscila C Cristovam, José A P Gomes, José L Laus

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Regulation of Limbal Epithelial Stem Cells: Importance of the Niche.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gisele P ValdetaroOphthalmology Unit, Department of Small Animal Medicine and Surgery, Faculty of Agrarian and Veterinary Sciences, UNESP Jaboticabal, 14884-900, SP, Brazil.
Marcela AldrovaniOphthalmology Unit, Department of Small Animal Medicine and Surgery, Faculty of Agrarian and Veterinary Sciences, UNESP Jaboticabal, 14884-900, SP, Brazil.
Ivan R M PaduaOphthalmology Unit, Department of Small Animal Medicine and Surgery, Faculty of Agrarian and Veterinary Sciences, UNESP Jaboticabal, 14884-900, SP, Brazil.
Priscila C CristovamOcular Surface Advanced Center, Federal University of São Paulo, UNIFESP São Paulo, 04039-002, SP, Brazil.
José A P GomesOcular Surface Advanced Center, Federal University of São Paulo, UNIFESP São Paulo, 04039-002, SP, Brazil.
José L LausOphthalmology Unit, Department of Small Animal Medicine and Surgery, Faculty of Agrarian and Veterinary Sciences, UNESP Jaboticabal, 14884-900, SP, Brazil.
Universidade Estadual Paulista (Unesp) · BRSurface (Brazil) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this research we evaluated the supramolecular organizations and the optical anisotropical properties of the de-epithelialized human amniotic membrane and rabbit limbal stroma, before and after explant culture. Birefringence, monochromatic light spectral absorption and linear dichroism of the main extracellular matrix biopolymers, that is, the fibrillar collagens and proteoglycans, were investigated by polarized light microscopy combined with image analysis. Our results demonstrated that the culture procedure-induced stimuli altered the supra-organizational characteristics (in terms of collagens/proteoglycans spatial orientation and ordered-aggregational state) of the amniotic and limbal extracellular matrix, which led to changes in optical anisotropical properties.

Indexed as

(000.1430) Biology and medicine(100.1930) Dichroism(160.1190) Anisotropic optical materials(170.4470) Ophthalmology(260.1440) Birefringence(260.5430) Polarization

Identifiers

PMID28018719
PMCPMC5175546
OpenAlexW2550569355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.