ArticleBiomedical optics express2016
Cerebral capillary velocimetry based on temporal OCT speckle contrast.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Cortical microvascular blood flow velocity mapping by combining dynamic light scattering optical coherence tomography and two-photon microscopy.Journal of biomedical optics · 2023Article
- Measuring capillary flow dynamics using interlaced two-photon volumetric scanning.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Dissecting the microvascular contributions to diffuse correlation spectroscopy measurements of cerebral hemodynamics using optical coherence tomography angiography.Neurophotonics · 2021Article
- Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography.Biomedical optics express · 2019Article
- Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography.Neurobiology of aging · 2018Article
- Capillary flow homogenization during functional activation revealed by optical coherence tomography angiography based capillary velocimetry.Scientific reports · 2018Article
- Capillary red blood cell velocimetry by phase-resolved optical coherence tomography.Optics letters · 2017Article
- Homocysteine-induced peripheral microcirculation dysfunction in zebrafish and its attenuation by L-arginine.Oncotarget · 2017Article
- Can OCT Angiography Be Made a Quantitative Blood Measurement Tool?Applied sciences (Basel, Switzerland) · 2017Article
- Optical coherence tomography angiography-based capillary velocimetry.Journal of biomedical optics · 2017Article
- Speckle variance optical coherence tomography of blood flow in the beating mouse embryonic heart.Journal of biophotonics · 2017Article
- Image-Guided Laparoscopic Surgical Tool (IGLaST) Based on the Optical Frequency Domain Imaging (OFDI) to Prevent Bleeding.Sensors (Basel, Switzerland) · 2017Article
- Hematocrit dependence of flow signal in optical coherence tomography angiography.Biomedical optics express · 2017Article
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Authors and funding
4 authors.
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Abstract
We propose a new optical coherence tomography (OCT) based method to measure red blood cell (RBC) velocities of single capillaries in the cortex of rodent brain. This OCT capillary velocimetry exploits quantitative laser speckle contrast analysis to estimate speckle decorrelation rate from the measured temporal OCT speckle signals, which is related to microcirculatory flow velocity. We hypothesize that OCT signal due to sub-surface capillary flow can be treated as the speckle signal in the single scattering regime and thus its time scale of speckle fluctuations can be subjected to single scattering laser speckle contrast analysis to derive characteristic decorrelation time. To validate this hypothesis, OCT measurements are conducted on a single capillary flow phantom operating at preset velocities, in which M-mode B-frames are acquired using a high-speed OCT system. Analysis is then performed on the time-varying OCT signals extracted at the capillary flow, exhibiting a typical inverse relationship between the estimated decorrelation time and absolute RBC velocity, which is then used to deduce the capillary velocities. We apply the method to
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