Evidence map›Paper›PMID 28018709›Full record

ArticleBiomedical optics express2016

Segmentation guided registration of wide field-of-view retinal optical coherence tomography volumes.

José Lezama, Dibyendu Mukherjee, Ryan P McNabb, Guillermo Sapiro, Anthony N Kuo, Sina Farsiu

Abstract read
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Volumetric montaging of optical coherence tomography in human retinas.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

José LezamaDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA.
Dibyendu MukherjeeDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Ryan P McNabbDepartment of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA.
Guillermo SapiroDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA.
Anthony N KuoDepartment of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA.
Sina FarsiuDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708, USA; Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA.

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3M
Whole Eye Optical Coherence Tomography to Improve Refractive Surgery and Eye CareR01EY024312 · NEI · DUKE UNIVERSITY · PI KUO, ANTHONY NANLIN · 2015 to 2024
$3.5M
Computer Aided Classification of Diabetic Macular EdemaR01EY022691 · NEI · DUKE UNIVERSITY · PI FARSIU, SINA · 2012 to 2016
$1.9M
NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY022691NEI NIH HHS R01 EY024312
6 · The paper itself

Abstract

Patient motion artifacts are often visible in densely sampled or large wide field-of-view (FOV) retinal optical coherence tomography (OCT) volumes. A popular strategy for reducing motion artifacts is to capture two orthogonally oriented volumetric scans. However, due to larger volume sizes, longer acquisition times, and corresponding larger motion artifacts, the registration of wide FOV scans remains a challenging problem. In particular, gaps in data acquisition due to eye motion, such as saccades, can be significant and their modeling becomes critical for successful registration. In this article, we develop a complete computational pipeline for the automatic motion correction and accurate registration of wide FOV orthogonally scanned OCT images of the human retina. The proposed framework utilizes the retinal boundary segmentation as a guide for registration and requires only a minimal transformation of the acquired data to produce a successful registration. It includes saccade detection and correction, a custom version of the optical flow algorithm for dense lateral registration and a linear optimization approach for axial registration. Utilizing a wide FOV swept source OCT system, we acquired retinal volumes of 12 subjects and we provide qualitative and quantitative experimental results to validate the state-of-the-art effectiveness of the proposed technique. The source code corresponding to the proposed algorithm is available online.

Indexed as

(100.2980) Image enhancement(170.4470) Ophthalmology(170.4500) Optical coherence tomography

Identifiers

PMID28018709
PMCPMC5175535

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.