Evidence map›Paper›PMID 28018601›Full record

ArticleJournal for immunotherapy of cancer2016

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia.

Michael Boyiadzis, Michael R Bishop, Rafat Abonour, Kenneth C Anderson, Stephen M Ansell, David Avigan, Lisa Barbarotta, Austin John Barrett, Koen Van Besien, P Leif Bergsagel and 38 more

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Commonly Reported Adverse Events Associated With Pediatric Immunotherapy: A Systematic Review From the Children's Oncology GroupJournal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses
    Pooled it
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  14. Primary Gastric Lymphoma, Epidemiology, Clinical Diagnosis, and Treatment.Cancer control : journal of the Moffitt Cancer Center
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 20 institutions in 4 countries.

Michael Boyiadzis *Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, 5150 Centre Avenue, Suite 564, Pittsburg, PA 15232 USA.
Michael R Bishop *Hematopoietic Cellular Therapy Program, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637 USA.
Rafat AbonourIndiana University School of Medicine, 980 W. Walnut St., Walther Hall-R3, C400, Indianapolis, IN 46202 USA.
Kenneth C AndersonDana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215 USA.
Stephen M AnsellMayo Clinic, 200 First Street SW, Rochester, MN 55905 USA.
David AviganBeth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215 USA.
Lisa BarbarottaSmilow Cancer Hospital at Yale New Haven, 35 Park Street, New Haven, CT 06519 USA.
Austin John BarrettNational Institutes of Health, Building 10-CRC Room 3-5330, Bethesda, MD 20814 USA.
Koen Van BesienWeill Cornell Medical College, 407 E 71st St, New York, NY 10065 USA.
P Leif BergsagelMayo Clinic, 13400 E. Shea Blvd., Scottsdale, AZ 85259 USA.
Ivan BorrelloJohns Hopkins School of Medicine, 1650 Orleans St, Baltimore, MD 21231 USA.
Joshua BrodyIcahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029 USA.
Jill BrufskyUniversity of Pittsburgh Cancer Institute, 5150 Centre Avenue, Pittsburgh, PA 15232 USA.
Mitchell CairoNew York Medical College at Maria Fareri Children's Hospital, 100 Woods Road, Valhalla, New York 10595 USA.
Ajai ChariIcahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029 USA.
Adam CohenAbramson Cancer Center at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104 USA.
Jorge CortesMD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 USA.
Stephen J FormanCity of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 USA.
Jonathan W FriedbergWilmot Cancer Institute, University of Rochester, 601 Elmwood Avenue, Box 704, Rochester, NY 14642 USA.
Ephraim J FuchsJohns Hopkins University School of Medicine, 401 N. Broadway, Baltimore, MD 21231 USA.
Steven D GoreYale Cancer Center, 333 Cedar Street, New Haven, CT 06511 USA.
Sundar JagannathIcahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029 USA.
Brad S KahlWashington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110 USA.
Justin KlineThe University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637 USA.
James N KochenderferNational Institutes of Health, National Cancer Institute, 8500 Roseweood Drive, Bethesda, MD 20814 USA.
Larry W KwakCity of Hope National Medical Center, 1500 E. Duarte Road, Beckman Bldg., Room 4117, Duarte, CA 91010 USA.
Ronald LevyDivision of Medical Oncology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305 USA.
Marcos de LimaDepartment of Medicine-Hematology and Oncology, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106 USA.
Mark R LitzowDepartment of Hematology, Mayo Clinic Cancer Center, 200 First Street SW, Rochester, MN 55905 USA.
Anuj MahindraHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, Box 0324, San Francisco, CA 94143 USA.
Jeffrey MillerDivision of Hematology/Oncology, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455 USA.
Nikhil C MunshiDana-Farber Cancer Institute, 450 Brookline Avenue, Dana B106, Boston, MA 02215 USA.
Robert Z OrlowskiThe University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 429, Houston, TX 77030 USA.
John M PagelSwedish Cancer Institute, 1221 Madison Street, Suite 1020, Seattle, WA 98104 USA.
David L PorterUniversity of Pennsylvania, 3400 Civic Center Blvd, PCAM 12 South Pavilion, Philadelphia, PA 19104 USA.
Stephen J RussellMayo Clinic, 200 First Street SW, Rochester, MN 55905 USA.
Karl SchwartzPatients Against Lymphoma, 3774 Buckwampum Road, Riegelsville, PA 18077 USA.
Margaret A ShippDana-Farber Cancer Institute, 450 Brookline Ave, Mayer 513, Boston, MA 02215 USA.
David SiegelHackensack University Medical Center, 92 2nd St., Hackensack, NJ 07601 USA.
Richard M StoneDana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215 USA.
Martin S TallmanMemorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.
John M TimmermanUniversity of California, Los Angeles, 10833 LeConte Ave., Los Angeles, CA 90095 USA.
Frits Van RheeUniversity of Arkansas for Medical Sciences, Myeloma Institute, 4301 W Markham #816, Little Rock, AR 72205 USA.
Edmund K WallerWinship Cancer Institute, Emory University, 1365B Clifton Road NE, Atlanta, GA 30322 USA.
Ann WelshUniversity of Pittsburgh Medical Center, 200 Lothrop St., Pittsburgh, PA 15213 USA.
Michael WernerPatient Advocate, 33 East Bellevue Place, Chicago, IL 60611 USA.
Peter H WiernikCancer Research Foundation of New York, 43 Longview Lane, Chappaqua, NY 10514 USA.
Madhav V DhodapkarDepartment of Hematology & Immunobiology, Yale University, 333 Cedar Street, Box 208021, New Haven, CT 06510 USA.
Dana-Farber Cancer Institute · USCancer Institute (WIA) · INIcahn School of Medicine at Mount Sinai · USWinnMed · USCity Of Hope National Medical Center · USNational Institutes of Health · USUniversity of Chicago · USUPMC Hillman Cancer Center · USBeth Israel Deaconess Medical Center · USCalifornia University of Pennsylvania · USCase Western Reserve University · USCornell University · USHackensack University Medical Center · USIndiana University · USJohns Hopkins Medicine · USLung Cancer Research Foundation · USMaria Fareri Children's Hospital · USMayo Clinic · USMemorial Sloan Kettering Cancer Center · USPatient Advocate Foundation · US

Funding

Trial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI John E. Wagner · 1995 to 2026
$48.2M
Therapeutic Potential of Adaptive NK Cells in Cancer and TransplantationP01CA111412 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FELICES, MARTIN · 2005 to 2025
$38.2M
Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Peter Leif Bergsagel · 2015 to 2026
$25.5M
Targeting Epigenomics in Myeloid NeoplasmsK24CA111717 · NCI · YALE UNIVERSITY · PI GORE, STEVEN D · 2005 to 2015
$1.7M
NCI NIH HHS K24 CA111717NCI NIH HHS P01 CA065493NCI NIH HHS P01 CA111412NCI NIH HHS P50 CA186781
6 · The paper itself

Abstract

Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval of immunotherapies that are resulting in impressive clinical responses. Therefore, the Society for Immunotherapy of Cancer (SITC) convened a hematologic malignancy Cancer Immunotherapy Guidelines panel consisting of physicians, nurses, patient advocates, and patients to develop consensus recommendations for the clinical application of immunotherapy for patients with multiple myeloma, lymphoma, and acute leukemia. These recommendations were developed following the previously established process based on the Institute of Medicine's clinical practice guidelines. In doing so, a systematic literature search was performed for high-impact studies from 2004 to 2014 and was supplemented with further literature as identified by the panel. The consensus panel met in December of 2014 with the goal to generate consensus recommendations for the clinical use of immunotherapy in patients with hematologic malignancies. During this meeting, consensus panel voting along with discussion were used to rate and review the strength of the supporting evidence from the literature search. These consensus recommendations focus on issues related to patient selection, toxicity management, clinical endpoints, and the sequencing or combination of therapies. Overall, immunotherapy is rapidly emerging as an effective therapeutic strategy for the management of hematologic malignances. Evidence-based consensus recommendations for its clinical application are provided and will be updated as the field evolves.

Indexed as

Acute leukemiaCancer immunotherapyHematologic malignanciesImmunotherapyLymphomaMultiple myeloma

Identifiers

PMID28018601
PMCPMC5168808
OpenAlexW2557349465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.