ReviewBoneKEy reports2016
Prophylactic augmentation of the osteoporotic proximal femur-mission impossible?
Review in BoneKEy reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Prophylactic fixation in elderly fractures: Preventive breakthrough or unnecessary intervention?World journal of orthopedics · 2025Review
- How accurately do finite element models predict the fall impact response of ex vivo specimens augmented by prophylactic intramedullary nailing?Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- The minimally invasive surgical local osteo-enhancement procedure (LOEP) to deliver a resorbable, tri-phasic calcium-based implant material to address bone loss and strengthen the proximal femur.Frontiers in surgery · 2025Article
- Is Regional Bone Mineral Density the Differentiating Factor Between Femoral Neck and Femoral Trochanteric Fractures?Cureus · 2024Article
- Gaps and alternative surgical and non-surgical approaches in the bone fragility management: an updated review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Review
- [Cement augmentation and bone graft substitutes-Materials and biomechanics].Unfallchirurgie (Heidelberg, Germany) · 2022Review
- Experimental validation of a voxel-based finite element model simulating femoroplasty of lytic lesions in the proximal femur.Scientific reports · 2022Article
- Finite Element Evaluation of the Femoral Neck System as Prophylactic Fixation to Prevent Contralateral Hip Fractures.Geriatric orthopaedic surgery & rehabilitation · 2022Article
- Simulating Prophylactic Fixation Methods for Osteoporotic Femoral Neck Fracture Prevention.Geriatric orthopaedic surgery & rehabilitation · 2022Article
- Finite Element Analysis of Cannulated Screws as Prophylactic Intervention of Hip Fractures.Geriatric orthopaedic surgery & rehabilitation · 2021Article
- Hip Fracture Prevention in Osteoporotic Elderly and Cancer Patients: An On-Line French Survey Evaluating Current Needs.Medicina (Kaunas, Lithuania) · 2020Article
- Finite element models for fracture prevention in patients with metastatic bone disease. A literature review.Bone reports · 2020Review
- Treatment of bone loss in proximal femurs of postmenopausal osteoporotic women with AGN1 local osteo-enhancement procedure (LOEP) increases hip bone mineral density and hip strength: a long-term prospective cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- In vitro injection of osteoporotic cadaveric femurs with a triphasic calcium-based implant confers immediate biomechanical integrity.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high incidence of secondary hip fractures and the associated markedly increased mortality call for preventive actions that could help to avoid these injuries. By providing immediate strengthening and not relying on patient compliance, internal prophylactic augmentation of the osteoporotic proximal femur may overcome the main limitations of systemic bone drugs and wearable protective pads. However, such a method would have to provide sufficient and reliable strengthening effect with minimal risks and side effects to justify the need of an invasive treatment. The requirements for an internal reinforcement approach are thus strict and include mechanical, biological, clinical, ethical and financial criteria. Here we first attempt to describe the properties of an ideal augmentation method. Previously published methodologies and techniques developed at our research institute, including approaches using cements, metals, other materials or combined approaches, are then reviewed and evaluated according to these aspects. We conclude that none of the discussed methodologies appears to be able to deliver a sufficiently high gain-versus-risk ratio that could justify the clinical application and thus augmentation of the osteoporotic proximal femur remains a challenge. Finally, we provide suggestions for the development and evaluation of future strategies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.