ArticleJournal of occupational medicine and toxicology (London, England)2016
Differential activation of RAW 264.7 macrophages by size-segregated crystalline silica.
Article in Journal of occupational medicine and toxicology (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Characterization of engineered stone dust-induced reactive oxygen species generation and cytotoxicityJournal of toxicology and environmental health. Part A · 2026Article
- Toxicity of respirable coal dust: An overview of origin, chemistry, mechanisms, and possible remedies.International journal of coal science & technology · 2026Review
- Exploring agglomeration of respirable silica and other particles in coal mine dust.Scientific reports · 2025Article
- Physicochemical Characteristics and Their Variation of Coal Dust Originating from Underground Mining Sites.ACS omega · 2025Article
- Field study demonstrates inordinate respirable dust generation during continuous mining in rock versus coal strata.International journal of coal science & technology · 2025Article
- Unveiling the threat of crystalline silica on the cardiovascular system. A comprehensive review of the current knowledge.Frontiers in cardiovascular medicine · 2025Review
- Article
- Characterization of particle exposure during tunnel excavation by tunnel boring machines.Annals of work exposures and health · 2024Article
- The impact of coal mine dust characteristics on pathways to respiratory harm: investigating the pneumoconiotic potency of coals.Environmental geochemistry and health · 2023Review
- Top-Down Preparation of Nanoquartz for Toxicological Investigations.International journal of molecular sciences · 2022Article
- Pulmonary Toxicity of Silica Linked to Its Micro- or Nanometric Particle Size and Crystal Structure: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages.Frontiers in immunology · 2022Review
- Metabolic Adaptation of Macrophages as Mechanism of Defense against Crystalline Silica.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Centrality of Myeloid-Lineage Phagocytes in Particle-Triggered Inflammation and Autoimmunity.Frontiers in toxicology · 2021Review
- Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance.Journal of inflammation research · 2021Article
- Aerodynamic size separation of glass fiber aerosols.Journal of occupational and environmental hygiene · 2020Article
- Pro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model.Particle and fibre toxicology · 2020Article
- Respirable coal mine dust at surface mines, United States, 1982-2017.American journal of industrial medicine · 2020Article
- Modulation of Immune Responses by Particle Size and Shape.Frontiers in immunology · 2020Review
- miR-1224-5p Mediates Mitochondrial Damage to Affect Silica-Induced Pulmonary Fibrosis by Targeting BECN1.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundOccupational exposure to crystalline silica is a well-established occupational hazard. Once in the lung, crystalline silica particles can result in the activation of alveolar macrophages (AM), potentially leading to silicosis, a fibrotic lung disease. Because the activation of alveolar macrophages is the beginning step in a complicated inflammatory cascade, it is necessary to define the particle characteristics resulting in this activation. The aim of this research was to determine the effect of the size of crystalline silica particles on the activation of macrophages.
methodsRAW 264.7 macrophages were exposed to four different sizes of crystalline silica and their activation was measured using electron microscopy, reactive oxygen species (ROS) generation by mitochondria, and cytokine expression.
resultsThese data identified differences in particle uptake and formation of subcellular organelles based on particle size. In addition, these data show that the smallest particles, with a geometric mean of 0.3 μm, significantly increase the generation of mitochondrial ROS and the expression of cytokines when compared to larger crystalline silica particles, with a geometric mean of 4.1 μm.
conclusionIn summary, this study presents novel data showing that crystalline silica particles with a geometric mean of 0.3 μm enhance the activation of AM when compared to larger silica particles usually represented in in vitro and in vivo research.
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