Evidence map›Paper›PMID 28018425›Full record

ArticleFrontiers in genetics2016

The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem.

Mehdi Maadooliat, Naveen K Bansal, Jiblal Upadhya, Manzur R Farazi, Xiang Li, Max M He, Scott J Hebbring, Zhan Ye, Steven J Schrodi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mehdi MaadooliatDepartment of Mathematics, Statistics and Computer Science, Marquette UniversityMilwaukee, WI, USA; Center for Human Genetics, Marshfield Clinic Research FoundationMarshfield, WI, USA.
Naveen K BansalDepartment of Mathematics, Statistics and Computer Science, Marquette University Milwaukee, WI, USA.
Jiblal UpadhyaDepartment of Mathematics, Statistics and Computer Science, Marquette University Milwaukee, WI, USA.
Manzur R FaraziDepartment of Mathematics, Statistics and Computer Science, Marquette University Milwaukee, WI, USA.
Xiang LiBiomedical Informatics Research Center, Marshfield Clinic Research Foundation Marshfield, WI, USA.
Max M HeCenter for Human Genetics, Marshfield Clinic Research FoundationMarshfield, WI, USA; Biomedical Informatics Research Center, Marshfield Clinic Research FoundationMarshfield, WI, USA; Computation and Informatics in Biology and Medicine, University of Wisconsin-MadisonMadison, WI, USA.
Scott J HebbringCenter for Human Genetics, Marshfield Clinic Research FoundationMarshfield, WI, USA; Computation and Informatics in Biology and Medicine, University of Wisconsin-MadisonMadison, WI, USA.
Zhan YeBiomedical Informatics Research Center, Marshfield Clinic Research Foundation Marshfield, WI, USA.
Steven J SchrodiCenter for Human Genetics, Marshfield Clinic Research FoundationMarshfield, WI, USA; Computation and Informatics in Biology and Medicine, University of Wisconsin-MadisonMadison, WI, USA.

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Biological Determinants of Brain Variation in AutismR01MH097464 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI LAINHART, JANET ELIZABETH, LANGE, NICHOLAS T · 2013 to 2017
$2.9M
PheWAS of Loss-of-Function VariantsR01GM114128 · NIGMS · MARSHFIELD CLINIC RESEARCH FOUNDATION · PI HEBBRING, SCOTT JOSEPH · 2015 to 2019
$1.7M
Development and Application of Phenome-wide Scan of Heritability (PheSH)K22LM011938 · NLM · MARSHFIELD CLINIC RESEARCH FOUNDATION · PI HEBBRING, SCOTT JOSEPH · 2014 to 2016
$405k
NCATS NIH HHS UL1 TR000427NIGMS NIH HHS R01 GM114128NIMH NIH HHS R01 MH097464NLM NIH HHS K22 LM011938
6 · The paper itself

Abstract

Several important and fundamental aspects of disease genetics models have yet to be described. One such property is the relationship of disease association statistics at a marker site closely linked to a disease causing site. A complete description of this two-locus system is of particular importance to experimental efforts to fine map association signals for complex diseases. Here, we present a simple relationship between disease association statistics and the decline of linkage disequilibrium from a causal site. Specifically, the ratio of Chi-square disease association statistics at a marker site and causal site is equivalent to the standard measure of pairwise linkage disequilibrium,

Indexed as

disease associationdisease geneticsfine-mappinglinkage disequilibriummode of inheritancestatistical genetics/genomicstheoretical geneticstwo-site model

Identifiers

PMID28018425
PMCPMC5149547

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.