ArticleFrontiers in endocrinology2016
Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing's Syndrome.
Article in Frontiers in endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Transformative applications of oculomics-based AI approaches in the management of systemic diseases: A systematic review.Journal of advanced research · 2025Pooled it
- Hypercortisolism and ocular microcirculation: exploring retinal and choroidal remodeling in Cushing's disease.International journal of ophthalmology · 2026Article
- Association of Central Serous Chorioretinopathy With Endogenous or Exogenous Corticosteroids: A Report of 2 Cases.JCEM case reports · 2025Article
- Pachychoroid Spectrum Diseases in Patients with Cushing's Syndrome: A Systematic Review with Meta-Analyses.Journal of clinical medicine · 2022Review
- Pachychoroid spectrum disease and choriocapillary flow analysis in patients with Cushing disease: an optical coherence tomography angiography study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Observational
- Effects of Ketoconazole on the Clinical Recovery in Central Serous Chorioretinopathy.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Central serous chorioretinopathy in active endogenous Cushing's syndrome.Scientific reports · 2021Observational
- Choroidal Vascular Characteristics in Subclinical Cushing Syndrome: A Cross-Sectional Pilot Study using Enhanced Depth Imaging Optical Coherence Tomography and Optical Coherence Tomography Angiography.Journal of current ophthalmologyArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextCortisol has been suggested as a risk factor for choroidal thickening, which may lead to retinal changes.
objectiveTo compare choroidal thickness measurements using optical coherence tomography (OCT) in patients with endogenous active Cushing's syndrome (CS) and to evaluate the occurrence of retinal abnormalities in the same group of patients.
designCross-sectional study.
settingOutpatient clinic. PATIENTS: Eleven female patients with CS in hypercortisolism state as determined by the presence of at least two abnormal measurements from urinary cortisol 24 h, no suppression of cortisol with low dose dexamethasone suppression test, and nocturnal salivary cortisol levels and 12 healthy controls.
methodsChoroidal and retinal morphology was assessed using OCT.
main outcome measuresChoroidal thickness measurements and the presence of retinal changes.
resultsThe mean subfoveal choroidal thickness was 372.96 ± 73.14 µm in the patients with CS and 255.63 ± 50.70 µm in the control group (
conclusionChoroidal thickness is increased in the eyes of patients with active CS compared to healthy and matched control. Also, 18.18% of patients presented with macular changes, possibly secondary to choroidal thickening. While further studies are necessary to confirm our findings, excess corticosteroid levels seem to have a significant effect on the choroid and might be associated with secondary retinal diseases.
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