ReviewFrontiers in physiology2016
Diaphragm Muscle Adaptation to Sustained Hypoxia: Lessons from Animal Models with Relevance to High Altitude and Chronic Respiratory Diseases.
Review in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Plasticity and evolved changes in mitochondrial physiology across skeletal muscles of high-altitude deer mice (Peromyscus maniculatus).The Journal of experimental biology · 2026Article
- Slow and fast locomotor muscle adaptations to sustained intermittent hypoxaemia.The journal of physiological sciences : JPS · 2026Article
- Forgotten muscle: diaphragm and sudden infant death syndrome.World journal of pediatrics : WJP · 2026Article
- Short-Term Simulated High-Altitude Hypoxia Enhances Na,K-ATPase Efficiency in Maintaining Rat Diaphragm Electrogenesis.Bulletin of experimental biology and medicine · 2025Article
- Chronic sustained hypoxia alters the pattern of diaphragm electrical activity in anaesthetized rats.Experimental physiology · 2025Article
- Chronic N-acetyl cysteine treatment does not improve respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy.Experimental physiology · 2024Article
- Short-Term Mild Hypoxia Modulates Na,K-ATPase to Maintain Membrane Electrogenesis in Rat Skeletal Muscle.International journal of molecular sciences · 2022Article
- Diaphragm Dysfunction and Rehabilitation Strategy in Patients With Chronic Obstructive Pulmonary Disease.Frontiers in physiology · 2022Review
- Re-Evaluating the Oxidative Phenotype: Can Endurance Exercise Save the Western World?Antioxidants (Basel, Switzerland) · 2021Review
- Functional, Ultrastructural, and Transcriptomic Changes in Rat Diaphragms with Different Durations of Cigarette Smoke Exposure.International journal of chronic obstructive pulmonary disease · 2020Article
- Characterizing the influence of chronic hypobaric hypoxia on diaphragmatic myofilament contractile function and phosphorylation in high-altitude deer mice and low-altitude white-footed mice.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Cardiopulmonary and Muscular Interactions: Potential Implications for Exercise (In)tolerance in Symptomatic Smokers Without Chronic Obstructive Pulmonary Disease.Frontiers in physiology · 2019Review
- Sustained Intermittent Hypoxemia Induces Adiponectin Oligomers Redistribution and a Tissue-Specific Modulation of Adiponectin Receptor in Mice.Frontiers in physiology · 2019Article
- A maladaptive ER stress response triggers dysfunction in highly active muscles of mice with SELENON loss.Redox biology · 2019Article
- Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine.Oxidative medicine and cellular longevity · 2018Article
- Tempol Supplementation Restores Diaphragm Force and Metabolic Enzyme Activities in mdx Mice.Antioxidants (Basel, Switzerland) · 2017Article
- Respiratory muscle dysfunction in animal models of hypoxic disease: antioxidant therapy goes from strength to strength.Hypoxia (Auckland, N.Z.) · 2017Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diaphragm is the primary inspiratory pump muscle of breathing. Notwithstanding its critical role in pulmonary ventilation, the diaphragm like other striated muscles is malleable in response to physiological and pathophysiological stressors, with potential implications for the maintenance of respiratory homeostasis. This review considers hypoxic adaptation of the diaphragm muscle, with a focus on functional, structural, and metabolic remodeling relevant to conditions such as high altitude and chronic respiratory disease. On the basis of emerging data in animal models, we posit that hypoxia is a significant driver of respiratory muscle plasticity, with evidence suggestive of both compensatory and deleterious adaptations in conditions of sustained exposure to low oxygen. Cellular strategies driving diaphragm remodeling during exposure to sustained hypoxia appear to confer hypoxic tolerance at the expense of peak force-generating capacity, a key functional parameter that correlates with patient morbidity and mortality. Changes include, but are not limited to: redox-dependent activation of hypoxia-inducible factor (HIF) and MAP kinases; time-dependent carbonylation of key metabolic and functional proteins; decreased mitochondrial respiration; activation of atrophic signaling and increased proteolysis; and altered functional performance. Diaphragm muscle weakness may be a signature effect of sustained hypoxic exposure. We discuss the putative role of reactive oxygen species as mediators of both advantageous and disadvantageous adaptations of diaphragm muscle to sustained hypoxia, and the role of antioxidants in mitigating adverse effects of chronic hypoxic stress on respiratory muscle function.
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