ArticleFrontiers in neural circuits2016
Mapping Horizontal Spread of Activity in Monkey Motor Cortex Using Single Pulse Microstimulation.
Article in Frontiers in neural circuits, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Learning induces activation-mechanism-dependent neural plasticity in an intracortical microstimulation task.Science advances · 2026Article
- Neural population dynamics of direct electrical stimulation of neocortex.Cell reports · 2026Article
- A Spatially Structured Spiking Network Model of Beta Traveling Waves and Their Attenuation in Motor Cortex.bioRxiv : the preprint server for biology · 2026Article
- Spatially Extensive LFP Correlations Identify Slow-Wave Sleep in Marmoset Sensorimotor Cortex.eNeuro · 2025Article
- Neural population dynamics of direct electrical stimulation of neocortex.bioRxiv : the preprint server for biology · 2025Article
- Training-Free Regulation of Grasping by Intracortical Tactile Feedback Designed via S1-M1 Communication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Continuous sensorimotor transformation enhances robustness of neural dynamics to perturbation in macaque motor cortex.Nature communications · 2025Article
- Circuits and mechanisms for TMS-induced corticospinal waves: Connecting sensitivity analysis to the network graph.PLoS computational biology · 2024Article
- Reconciliation of weak pairwise spike-train correlations and highly coherent local field potentials across space.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Article
- Emergence of task-related spatiotemporal population dynamics in transplanted neurons.Nature communications · 2023Article
- Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex.Nature communications · 2023Article
- Learning in a sensory cortical microstimulation task is associated with elevated representational stability.Nature communications · 2023Article
- Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice.eLife · 2023Article
- Propagating motor cortical patterns of excitability are ubiquitous across human and non-human primate movement initiation.iScience · 2023Article
- Article
- Stimulation-Evoked Effective Connectivity (SEEC): An in-vivo approach for defining mesoscale corticocortical connectivity.Journal of neuroscience methods · 2023Article
- Microstimulation of visual area V4 improves visual stimulus detection.Cell reports · 2022Article
- Characterizing the short-latency evoked response to intracortical microstimulation across a multi-electrode array.Journal of neural engineering · 2022Article
- Intracortical Microelectrode Array Unit Yield under Chronic Conditions: A Comparative Evaluation.Micromachines · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anatomical studies have demonstrated that distant cortical points are interconnected through long range axon collaterals of pyramidal cells. However, the functional properties of these intrinsic synaptic connections, especially their relationship with the cortical representations of body movements, have not been systematically investigated. To address this issue, we used multielectrode arrays chronically implanted in the motor cortex of two rhesus monkeys to analyze the effects of single-pulse intracortical microstimulation (sICMS) applied at one electrode on the neuronal activities recorded at all other electrodes. The temporal and spatial distribution of the evoked responses of single and multiunit activities was quantified to determine the properties of horizontal propagation. The typical responses were characterized by a brief excitatory peak followed by inhibition of longer duration. Significant excitatory responses to sICMS could be evoked up to 4 mm away from the stimulation site, but the strength of the response decreased exponentially and its latency increased linearly with the distance. We then quantified the direction and strength of the propagation in relation to the somatotopic organization of the motor cortex. We observed that following sICMS the propagation of neural activity is mainly directed rostro-caudally near the central sulcus but follows medio-lateral direction at the most anterior electrodes. The fact that these interactions are not entirely symmetrical may characterize a critical functional property of the motor cortex for the control of upper limb movements. Overall, these results support the assumption that the motor cortex is not functionally homogeneous but forms a complex network of interacting subregions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.